Aneke John C, Adegoke Adegbola O, Osho Patrick O, Okocha Emmanuel C, Nancy Ibeh C, Akintola Norah O, Durosinmi Muheez A
Niger J Med. 2016 Jan-Mar;25(1):60-9.
Individuals with sickle cell anaemia (SCA) have lower systemic blood pressures compared to individuals with haemoglobin Hb AA phenotype.
Seventy-nine (79) individuals with SCA (subjects) in steady state and 50 age-matched individuals with Hb AA (controls) were prospectively studied. Height, blood pressure (BP), weight, creatinine clearance (by 24-hour urine collection), full blood count (FBC) and reticulocyte count were obtained from all subjects and controls. Body mass index (BMI), corrected reticulocyte count, mean arterial pressure (MAP) and pulse pressure (PP) were calculated using standard protocols.The frequency of vaso-occlusive crises in the last one year and number of blood transfusions in the last two years were obtained from subjects. Data was analyzed using descriptive and inferential statistics and p ≤0.05 was used to define the level of statistical significance.
Seventy-nine (79) individuals with SCA (subjects) in steady state and 50 age-matched individuals with Hb AA (controls) were prospectively studied. Height, blood pressure (BP), weight, creatinine clearance (by 24-hour urine collection), full blood count (FBC) and reticulocyte count were obtained from all subjects and controls. Body mass index (BMI), corrected reticulocyte count, mean arterial pressure (MAP) and pulse pressure (PP) were calculated using standard protocols.The frequency of vaso-occlusive crises in the last one year and number of blood transfusions in the last two years were obtained from subjects. Data was analyzed using descriptive and inferential statistics and p ≤0.05 was used to define the level of statistical significance.
The systolic (105.52±11.75mmHg and 113.20±7.94mmHg respectively; P = 0.01), diastolic (62.59±9.33mmHg and 75.40±5.70mmHg respectively; P=0.03) and mean arterial pressures (76.90±8.81mmHg and 88.00±5.51mmHg respectively; P =0.04) were significantly lower in subjects when compared with controls. ; pulse pressure (PP) was however significantly higher in subjects than controls (42.92±10.91mmHg and 37.80±7.43mmHg respectively (P = 0.03). In female subjects, the white cell count was negatively correlated with systolic BP (r = -0.39;P = 0.01) and PP (r = -0.33; P = 0.03).
Lower systolic and pulse pressures may predict worsening disease severity in individuals with sickle cell anaemia.
与具有血红蛋白Hb AA表型的个体相比，镰状细胞贫血（SCA）患者的全身血压较低。
对79例处于稳定状态的SCA患者（研究对象）和50例年龄匹配的Hb AA患者（对照组）进行前瞻性研究。从所有研究对象和对照组获取身高、血压（BP）、体重、肌酐清除率（通过24小时尿液收集）、全血细胞计数（FBC）和网织红细胞计数。使用标准方案计算体重指数（BMI）、校正网织红细胞计数、平均动脉压（MAP）和脉压（PP）。从研究对象处获取过去一年血管闭塞性危机的发生频率以及过去两年的输血次数。使用描述性和推断性统计方法分析数据，以p≤0.05定义统计学显著性水平。
对79例处于稳定状态的SCA患者（研究对象）和50例年龄匹配的Hb AA患者（对照组）进行前瞻性研究。从所有研究对象和对照组获取身高、血压（BP）、体重、肌酐清除率（通过24小时尿液收集）、全血细胞计数（FBC）和网织红细胞计数。使用标准方案计算体重指数（BMI）、校正网织红细胞计数、平均动脉压（MAP）和脉压（PP）。从研究对象处获取过去一年血管闭塞性危机的发生频率以及过去两年的输血次数。使用描述性和推断性统计方法分析数据，以p≤0.05定义统计学显著性水平。
与对照组相比，研究对象的收缩压（分别为105.52±11.75mmHg和113.20±7.94mmHg；P = 0.01）、舒张压（分别为62.59±9.33mmHg和75.40±5.70mmHg；P = 0.03）和平均动脉压（分别为76.90±8.81mmHg和88.00±5.51mmHg；P = 0.04）显著较低；然而，研究对象的脉压（PP）显著高于对照组（分别为42.92±10.91mmHg和37.80±7.43mmHg；P = 0.03）。在女性研究对象中，白细胞计数与收缩压（r = -0.39；P = 0.01）和脉压（r = -0.33；P = 0.03）呈负相关。
较低的收缩压和脉压可能预示镰状细胞贫血患者疾病严重程度的恶化。
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