Hayes A G, Stewart B R
Eur J Pharmacol. 1985 Oct 8;116(1-2):75-9. doi: 10.1016/0014-2999(85)90186-4.
The effect of several mu and kappa opioid receptor agonists on rat plasma corticosterone levels, measured using radioimmunoassay, was investigated. The mu agonists, morphine and fentanyl, and the kappa agonists, U-50,488, tifluadom and bremazocine, all produced dose-related increases in rat plasma corticosterone levels. The effects of both fentanyl and U-50,488 were reversed by naloxone, indicating an action at opioid receptors. Pretreatment of the rats with the irreversible, mu-selective antagonist, beta-funaltrexamine, reduced the effect of fentanyl, but not that of U-50,488, indicating that both mu and kappa opioid receptors are involved in mediating this effect.
研究了几种μ和κ阿片受体激动剂对大鼠血浆皮质酮水平的影响，采用放射免疫分析法进行测定。μ激动剂吗啡和芬太尼，以及κ激动剂U-50,488、替氟朵和布瑞马佐辛，均使大鼠血浆皮质酮水平呈剂量相关升高。芬太尼和U-50,488的作用均被纳洛酮逆转，表明其作用于阿片受体。用不可逆的μ选择性拮抗剂β-氟纳曲胺对大鼠进行预处理，可降低芬太尼的作用，但不影响U-50,488的作用，表明μ和κ阿片受体均参与介导此效应。
