Pfützner Wolfgang, Brockow Knut
1Department of Dermatology and Allergology, University Hospital Marburg, Baldingerstraße, 35043 Marburg, Germany.
2Department of Dermatology and Allergology am Biederstein, Technical University of Munich, Munich, Germany.
Allergo J Int. 2018;27(4):126-129. doi: 10.1007/s40629-018-0071-1. Epub 2018 Jun 4.
Allergy testing for perioperative drug reactions poses a particular diagnostic challenge. Neuromuscular blocking agents (NMBA) and antibiotics are among the most common triggers. In principle, however, any drug administered perioperatively is capable of causing a hypersensitivity reaction.
This article is an overview of selected scientific articles and is based on research in PubMed, specialist databases, and guidelines.
Besides patient's history and laboratory tests (the latter being feasible to only a limited extent), skin tests play a particularly important role. To obtain clinical relevant results, profound knowledge on the best point in time for testing, the drug concentrations to be used, how to perform tests correctly, and the assessment criteria is of special importance.
Final outcomes of the diagnostic procedures should be providing thorough information of the patient about the findings, drugs that should be avoided in the future as well as alternative preparations, and, if necessary, preventive measures to be taken in the event of further surgical interventions.
围手术期药物反应的过敏测试带来了特殊的诊断挑战。神经肌肉阻滞剂（NMBA）和抗生素是最常见的触发因素。然而，原则上围手术期使用的任何药物都有可能引起过敏反应。
本文是对所选科学文章的概述，基于在PubMed、专业数据库和指南中的研究。
除了患者病史和实验室检查（后者在一定程度上可行）外，皮肤测试起着特别重要的作用。为了获得临床相关结果，深入了解测试的最佳时间点、所用药物浓度、如何正确进行测试以及评估标准尤为重要。
诊断程序的最终结果应向患者全面提供有关检查结果、未来应避免使用的药物以及替代制剂的信息，如有必要，还应提供在进一步手术干预时应采取的预防措施。
