Petrochemical Research Chair, Department of Chemistry, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
PG & Research Department of Chemistry, Nehru Memorial College, Puthanampatti, Tiruchirappalli (Dt), Tamil Nadu, 621007, India.
Mol Divers. 2019 Feb;23(1):35-53. doi: 10.1007/s11030-018-9850-3. Epub 2018 Jul 5.
Novel pyrazolidine-3,5-dione derivatives (2a-g, 4a-g, and 6a-g) were synthesized by an easy-to-perform Mg(II) acetylacetonate-catalyzed reaction with high yields using water as the reaction medium. Synthesized compounds were screened for anticancer and antimicrobial activities. The compound 6c (LD 19.1 µg/mL) showed anticancer activity higher than that of all other compounds against MCF-7 breast cancer cell line. Results of antimicrobial activities revealed that the compound 4d (MIC 0.5 μg/mL) had higher activity than ciprofloxacin against Staphylococcus aureus, whereas the compound 2b (MIC 0.5 μg/mL) had higher activity than clotrimazole against Candida albicans. Overall results of this study envisaged that the compounds 2b, 4d, and 6c have the potential to be developed as anticancer and antimicrobial agents. Novel pyrazolidine-3,5-dione derivatives (2a-g, 4a-g, and 6a-g) were synthesized via an easy-to perform Mg(II) catalysis in water medium. The synthesized compounds were screened for anticancer and antimicrobial activities.
新型吡唑烷-3,5-二酮衍生物（2a-g、4a-g 和 6a-g）通过在水介质中易于进行的 Mg(II) 乙酰丙酮酸盐催化反应以高产率合成。合成的化合物进行了抗癌和抗菌活性筛选。化合物 6c（LD 19.1μg/mL）对 MCF-7 乳腺癌细胞系的抗癌活性高于其他所有化合物。抗菌活性结果表明，化合物 4d（MIC 0.5μg/mL）对金黄色葡萄球菌的活性高于环丙沙星，而化合物 2b（MIC 0.5μg/mL）对白色念珠菌的活性高于克霉唑。这项研究的总体结果表明，化合物 2b、4d 和 6c 有可能被开发为抗癌和抗菌药物。新型吡唑烷-3,5-二酮衍生物（2a-g、4a-g 和 6a-g）通过在水介质中易于进行的 Mg(II) 催化作用合成。合成的化合物进行了抗癌和抗菌活性筛选。
Zotero 插件