Department of Laboratory Medicine, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District Shenyang, Liaoning 110004, PR China.
Biomark Med. 2018 Aug;12(8):927-935. doi: 10.2217/bmm-2018-0152. Epub 2018 Jul 6.
Urinary podocalyxin and nephrin are urine markers of podocyte dysfunction that may reflect the integrity of kidney's filtration barrier. Studies on their respective roles in glomerular diseases are still underway. However, the isolated and unsystematic manner in which they are being studied does not permit proper identification of their roles in each glomerular disease. As such, there is little or no appreciation of what research has already achieved and what remains to be achieved as the research direction is not clearly defined. We explored the recent studies and outlined the major findings regarding the value of both biomarkers in each of the three glomerular disease entities. Our review covered diabetic nephropathy, membranous nephropathy and IgA nephropathy.
尿足细胞蛋白和肾小球裂孔膜蛋白是反映肾小球滤过屏障完整性的足细胞功能障碍的尿标志物。关于它们在肾小球疾病中的各自作用的研究仍在进行中。然而，由于对它们的研究方式是孤立和不系统的，因此无法正确确定它们在每种肾小球疾病中的作用。因此，由于研究方向不明确，对于已经取得的成果和尚未取得的成果，人们的认识很少或没有。我们探讨了最近的研究，并概述了这两种生物标志物在三种肾小球疾病实体中的每一种中的主要发现价值。我们的综述涵盖了糖尿病肾病、膜性肾病和 IgA 肾病。
