Stevens-Johnson and Lyell syndromes in children in a hospital setting in Lomé, Togo, from 2000 to 2015.
作者信息
Akakpo A B, Saka B, Abilogoun-Chokki A E, Teclessou J N, Mahamadou G, Gnassingbe W, Mouhari-Toure A, Kombate K, Pitche P
机构信息
Service dermatologie et IST, CHU Sylvanus Olympio, Université de Lomé, 14 BP 200 Lomé, Togo.
Service de dermatologie du CHU Kara, Université de Lomé, Togo.
出版信息
Med Sante Trop. 2018 May 1;28(2):332-333. doi: 10.1684/mst.2018.0797.
OBJECTIVE
The aim of this study was to document the profile of children with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN, also called Lyell syndrome) in hospital settings in Lomé, Togo.
METHOD
This descriptive retrospective study examined the records of children aged 0 to 15, seen and/or hospitalized in the dermatology department of CHU-SO Lomé and diagnosed with SJS/TEN between 2000 and 2015.
RESULTS
Records were identified for 14 children with these diagnoses during the study period. Their average age was 10.9 ± 3.9 years. The average time between taking the apparently causal medication and the onset of symptoms was 10.5 days (range: 4 to 21 days). SJS accounted for 64.3% of the cases. Six children with SJS and one with TEN had ocular involvement. Antibacterial sulfonamides were the main drug involved for 43% of children, followed by anticonvulsants for 14/3%.
CONCLUSION
Our results show that SJS/TEN is rare but serious in children. The antibacterial sulfonamides used for the treatment of malaria and anticonvulsants are their most frequent cause.
Zotero 插件