基板中的生后命运细化

Postmitotic Fate Refinement in the Subplate.

机构信息

Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA 94143, USA.

出版信息

Cell Stem Cell. 2018 Jul 5;23(1):7-9. doi: 10.1016/j.stem.2018.06.017.

DOI:10.1016/j.stem.2018.06.017

PMID:29979992

Abstract

How is the astonishing diversity of cortical neurons specified? In this issue of Cell Stem Cell, Ozair et al. (2018) leverage hPSC neural differentiation to show that projection neurons undergo prolonged sojourns in the subplate before migrating to deep layers, suggesting that pausing in the subplate may enable integration of intrinsic and extrinsic cues during postmitotic fate refinement.

摘要

皮质神经元惊人的多样性是如何产生的？在本期《细胞—干细胞》杂志中，Ozair 等人利用 hPSC 神经分化研究表明，投射神经元在迁移到深层之前会在基板中经历长时间的停留，这表明在基板中的暂停可能使内在和外在线索在细胞分裂后命运特化过程中得以整合。