Pirich K, Vierhapper H, Nowotny P
Wien Klin Wochenschr. 1985 Nov 8;97(21):806-8.
6 patients with Cushing's syndrome were investigated with regard to the effect of synthetic ovine corticotropin-releasing factor (o-CRF), administered as an intravenous bolus of 100 micrograms, on peripheral plasma concentrations of ACTH and cortisol. The purpose of this study was to evaluate the usefulness of this "CRF test" in the differential diagnosis of Cushing's syndrome as compared with conventional diagnostic procedures. 100 micrograms CRF caused a rise in plasma ACTH and cortisol in patients with bilateral adrenal hyperplasia (n = 3). However, in patients with cortisol-producing adrenal adenoma (n = 2) and ectopic ACTH overproduction (n = 1), no increase in plasma cortisol and ACTH was induced by exogenous CRF. We conclude from these findings that the CRF test will prove a valuable diagnostic tool to differentiate pituitary from extrapituitary forms of endogenous hypercortisolism in patients with Cushing's syndrome.
对6例库欣综合征患者进行了研究，给予100微克合成羊促肾上腺皮质激素释放因子（o-CRF）静脉推注，观察其对促肾上腺皮质激素（ACTH）和皮质醇外周血浆浓度的影响。本研究的目的是评估与传统诊断方法相比，这种“CRF试验”在库欣综合征鉴别诊断中的实用性。100微克CRF使双侧肾上腺增生患者（n = 3）的血浆ACTH和皮质醇升高。然而，在产生皮质醇的肾上腺腺瘤患者（n = 2）和异位ACTH分泌过多患者（n = 1）中，外源性CRF未引起血浆皮质醇和ACTH升高。我们从这些发现中得出结论，CRF试验将被证明是一种有价值的诊断工具，用于区分库欣综合征患者内源性皮质醇增多症的垂体性和垂体外形式。
