Fisher Robert, Zhou Jing, Fogarty Adam, Joshi Aditya, Markert Matthew, Deutsch Gayle K, Velez Mariel
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, United States.
Epilepsy Behav Case Rep. 2018 Apr 18;10:47-53. doi: 10.1016/j.ebcr.2018.03.004. eCollection 2018.
We demonstrate feasibility of using high-density EEG to map a neocortical seizure focus in conjunction with delivery of magnetic therapy. Our patient had refractory seizures affecting the left leg. A five-day course of placebo stimulation followed a month later by active rTMS was directed to the mapped seizure dipole. Active rTMS resulted in reduced EEG spiking, and shortening of seizure duration compared to placebo. Seizure frequency, however, improved similarly in both placebo and active treatment stages. rTMS-evoked EEG potentials demonstrated that a negative peak at 40 ms - believed to represent GABAergic inhibition - was enhanced by stimulation.
我们证明了结合磁疗使用高密度脑电图来绘制新皮层癫痫病灶的可行性。我们的患者患有影响左腿的难治性癫痫。在为期五天的安慰剂刺激疗程之后，一个月后对绘制出的癫痫偶极进行了主动重复经颅磁刺激（rTMS）。与安慰剂相比，主动rTMS导致脑电图尖峰减少，癫痫持续时间缩短。然而，癫痫发作频率在安慰剂和主动治疗阶段均有类似改善。rTMS诱发的脑电电位表明，刺激增强了40毫秒处的负峰，该负峰被认为代表γ-氨基丁酸能抑制。
