Rühle A, Huber P E
Abteilung für RadioOnkologie und Strahlentherapie, Universitätsklinik Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland.
KKE Molekulare und RadioOnkologie, Deutsches Krebsforschungszentrum (dkfz), Im Neuenheimer Feld 280, 69120, Heidelberg, Deutschland.
Radiologe. 2018 Aug;58(8):746-753. doi: 10.1007/s00117-018-0430-4.
Along with chemotherapy, surgery and immunotherapy, radiotherapy is a mainstay of cancer treatment. Considering the improving survival rates for various malignancies during the past decades, the importance of radiation-induced late normal tissue response is increasing. Quality of life is becoming an important issue in modern cancer treatment and is correlated with acute and late normal tissue response after radiotherapy. A profound understanding of radiation-induced normal tissue response is necessary to sufficiently diagnose and treat radiation-induced side effects and thereby increase the patients' quality of life. Here, the various normal tissue responses in consideration of the radiation biology are specified and prospective options to attenuate radiation-induced side effects are discussed.
与化疗、手术和免疫疗法一样，放射治疗是癌症治疗的主要手段。鉴于在过去几十年中各种恶性肿瘤的生存率不断提高，辐射诱发的晚期正常组织反应的重要性日益增加。生活质量正成为现代癌症治疗中的一个重要问题，并且与放疗后的急性和晚期正常组织反应相关。要充分诊断和治疗辐射诱发的副作用并从而提高患者的生活质量，深入了解辐射诱发的正常组织反应是必要的。在此，我们明确了考虑辐射生物学因素的各种正常组织反应，并讨论了减轻辐射诱发副作用的前瞻性选择。
