Rossi Alfredo, Caterina Fortuna Maria, Caro Gemma, Cardone Michele, Garelli Valentina, Grassi Sara, Carlesimo Marta
Department of Internal Medicine and Medical Specialties, "Sapienza" University of Rome, Rome, Italy.
Dermatology, Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
J Cosmet Dermatol. 2019 Apr;18(2):575-580. doi: 10.1111/jocd.12687. Epub 2018 Jul 11.
Chemotherapy-induced alopecia (CIA) ranks among the psychologically most devastating effects of cancer treatment for oncological patients, with an overall incidence of 65%. Nowadays trichoscopy is largely employed in the diagnosis of alopecia, but no description of CIA trichoscopic pattern is present in literature.
We want to create an organic description of CIA trichoscopic aspects.
Oncological patients candidate to chemotherapy drugs, afferent to our trichological outpatient were studied. Anamnesis, clinical exam, clinical global photography, pull test, trichogram, and trichoscopy were conducted at the different moments of therapeutic treatment.
A definite trichoscopic pattern in the different phases of treatment was observed. After the first 3 weeks of chemotherapy rare and scattered black dots, broken hairs, flame hairs and pohl pinkus appeared. At the end of chemotherapy besides the features described above, numerous thin hair in regrowth were detected, together to rare terminal hair, scattered black dots and circle hair. Three months after chemotherapy a progressive increase of follicular units and elongation of the existing hair were visible.
We propose an description of CIA trichoscopic pattern and its evolution during the different phases of chemotherapy.
化疗所致脱发（CIA）是肿瘤患者癌症治疗中对心理影响最大的副作用之一，总体发生率为65%。如今，毛发镜检查在脱发诊断中广泛应用，但文献中尚无关于CIA毛发镜特征的描述。
我们希望对CIA的毛发镜特征进行系统描述。
对前来我们毛发门诊就诊、准备接受化疗药物治疗的肿瘤患者进行研究。在治疗的不同阶段进行病史采集、临床检查、临床整体摄影、拔毛试验、毛发图谱分析和毛发镜检查。
观察到治疗不同阶段明确的毛发镜特征。化疗开始3周后，出现稀疏散在的黑点、断发、火焰状发和波氏小皮丘疹。化疗结束时，除上述特征外，还检测到大量再生的细发，以及罕见的终毛、散在黑点和环状发。化疗3个月后，可见毛囊单位逐渐增多，现有毛发伸长。
我们提出了CIA在化疗不同阶段的毛发镜特征及其演变的描述。
