Accurate Pelvis and Femur Segmentation in Hip CT With a Novel Patch-Based Refinement.

Due to bone deformation and joint space narrowing in diseased hips, accurate segmentation for pelvis, and femur from hip computed tomography (CT) images remains a challenging task. Therefore, the paper presents a fully automatic segmentation framework for the pelvis and femur in both of healthy and diseased hips. The framework involves three steps: preprocessing, coarse segmentation, and refinement. It starts with a preprocessing procedure to extract the volume of interest (VOI) from original CT images. Then, a coarse segmentation of bone has been obtained by classifying the VOI as bone and nonbone parts based on conditional random field (CRF) model. Finally, the bone is further divided into the pelvis and femur using a patch-based refinement method. The innovation of this study is the novel patch-based refinement method that is particularly suitable for diseased hips. The refinement method starts from the boundary of coarse segmentation, and propagates to the neighbors only when the label is not consistent with the label of CRF-based classification, it increases the reliability of segmentation for diseased hips with bone deformation. We incorporate neighborhood information to label fusion so that final label estimation is more accurate and robust for diseased hips with joint space narrowing. In total, 60 CT data sets, which included 78 healthy hemi-hips and 42 diseased hemi-hips, were used, and three-fold cross validations were carried out. Compared to two state-of-the-art methods, our method achieved significantly increased segmentation accuracy for the diseased hemi-hips, and is, therefore, more suited for automatic segmentation of diseased hips.