Fisher Jonathan, Anderson John
University College London, London, United Kingdom.
Front Immunol. 2018 Jun 26;9:1409. doi: 10.3389/fimmu.2018.01409. eCollection 2018.
Sharing both innate and adaptive immune properties, γδT cells are attractive candidates for cellular engineering. As the cancer immunotherapy field becomes increasingly busy, orthogonal approaches are required to drive advancement. Engineering of alternative effector cell types such as γδT cells represents one such approach. γδT cells can be modified using many of the techniques used in αβT cell engineering, with the added advantage of innate-like tumor recognition and killing. Progress has been made in T-cell receptor transfer to and from γδT cells as well as in a number of chimeric antigen receptor-based strategies. As the cancer immunotherapy field moves beyond repetitive iteration of established constructs to more creative solutions, γδT cells may offer an attractive chassis to drive anti-tumor responses that are not only broader, but also possess a more favorable safety profile.
γδT细胞兼具先天性和适应性免疫特性，是细胞工程中颇具吸引力的候选对象。随着癌症免疫治疗领域日益繁忙，需要采用正交方法来推动进展。工程改造诸如γδT细胞等替代效应细胞类型就是这样一种方法。γδT细胞可以使用许多用于αβT细胞工程的技术进行改造，具有类似先天性肿瘤识别和杀伤的额外优势。在T细胞受体向γδT细胞的转入和转出以及一些基于嵌合抗原受体的策略方面均取得了进展。随着癌症免疫治疗领域从既定构建体的重复迭代转向更具创造性的解决方案，γδT细胞可能提供一个有吸引力的框架，以驱动不仅更广泛而且具有更良好安全性的抗肿瘤反应。
