Hajjej Abdelhafidh, Almawi Wassim Y, Stayoussef Mouna, Arnaiz-Villena Antonio, Hattab Lasmar, Hmida Slama
a Department of Immunogenetics , National Blood Transfusion Center , Tunis , Tunisia.
b School of Pharmacy , Lebanese American University , Byblos , Lebanon.
Immunol Invest. 2019 Feb;48(2):130-146. doi: 10.1080/08820139.2018.1493498. Epub 2018 Jul 13.
Several studies confirmed the association of HLA-DRB1 and -DQB1 alleles with altered risk of type 1 diabetes (T1D). However, data from individual studies based on small sample sizes yielded often conflicting findings in African Arabs. This is a systematic review and meta-analysis aimed at comprehensively evaluating this association with T1D, using molecular HLA data. Relevant studies were identified through systemic search of Medline/PubMed, Cochrane, Science Direct, ResearchGate, and EMBASE databases. Statistical analysis was carried out using RevMan, and Comprehensive Meta-analysis programs. Given the heterogeneity of African Arabs, we also performed subgroup analysis according to ethnicity. Analysis of sensitivity, heterogeneity, and publication bias were performed to validate the outcome of the findings. This meta-analysis included 862 T1DM cases, along with 1,390 normoglycemic control, and comprised ten comparisons. Our study indicates that DRB103 (OR = 2.86), DRB104 (OR = 2.78), and DQB102 (OR = 2.29), are positively associated with increased risk of T1DM, while DRB107 (OR = 0.48), DRB111 (OR = 0.20), DRB113 (OR = 0.47), DRB115 (OR = 0.30), DQB105 (OR = 0.39), and DQB1*06 (OR = 0.27) were negatively associated with T1D, suggesting a protective role against T1D. This meta-analysis was characterized by low heterogeneity, sensitivity, and publication bias, indicating the robustness and reliability of the results.
Several studies confirmed the association of HLA-DRB1 and -DQB1 alleles with altered risk of type 1 diabetes (T1D). However, data from individual studies based on small sample sizes yielded often conflicting findings in African Arabs. This is a systematic review and meta-analysis aimed at comprehensively evaluating this association with T1D, using molecular HLA data.
Relevant studies were identified through systemic search of Medline/PubMed, Cochrane, Science Direct, ResearchGate, and EMBASE databases. Statistical analysis was carried out using Revman, and Comprehensive Meta-analysis programs. Given the heterogeneity of African Arabs, we also performed subgroup analysis according to ethnicity. Analysis of sensitivity, heterogeneity, and pub¬lication bias were performed to validate the outcome of the findings. This meta-analysis included 862 T1DM cases, along with 1,390 normoglycemic control, and comprised ten comparisons.
Our study indicates that DRB103 (OR = 2.86), DRB104 (OR = 2.78), and DQB102 (OR = 2.29), are positively associated with increased risk of T1DM, while DRB107 (OR = 0.48), DRB111 (OR = 0.20), DRB113 (OR = 0.47), DRB115 (OR = 0.30), DQB105 (OR = 0.39), and DQB1*06 (OR = 0.27) were negatively associated with T1D, suggesting a protective role against T1D.
This meta-analysis was characterized by low heterogeneity, sensitivity, and publication bias, indicating the robustness and reliability of the results.
多项研究证实了HLA - DRB1和 - DQB1等位基因与1型糖尿病（T1D）风险改变之间的关联。然而，基于小样本量的个别研究数据在非洲阿拉伯人群中常常得出相互矛盾的结果。这是一项系统评价和荟萃分析，旨在利用分子HLA数据全面评估这种与T1D的关联。通过系统检索Medline/PubMed、Cochrane、Science Direct、ResearchGate和EMBASE数据库来识别相关研究。使用RevMan和综合荟萃分析程序进行统计分析。鉴于非洲阿拉伯人群的异质性，我们还根据种族进行了亚组分析。进行敏感性、异质性和发表偏倚分析以验证研究结果。这项荟萃分析包括862例T1DM病例以及1390例血糖正常对照，共包含十项比较。我们的研究表明，DRB103（比值比[OR]=2.86）、DRB104（OR = 2.78）和DQB102（OR = 2.29）与T1DM风险增加呈正相关，而DRB107（OR = 0.48）、DRB111（OR = 0.20）、DRB113（OR = 0.47）、DRB115（OR = 0.30）、DQB105（OR = 0.39）和DQB1*06（OR = 0.27）与T1D呈负相关，表明对T1D有保护作用。这项荟萃分析具有低异质性、敏感性和发表偏倚的特点，表明结果的稳健性和可靠性。
多项研究证实了HLA - DRB1和 - DQB1等位基因与1型糖尿病（T1D）风险改变之间的关联。然而，基于小样本量的个别研究数据在非洲阿拉伯人群中常常得出相互矛盾的结果。这是一项系统评价和荟萃分析，旨在利用分子HLA数据全面评估这种与T1D的关联。
通过系统检索Medline/PubMed、Cochrane、Science Direct、ResearchGate和EMBASE数据库来识别相关研究。使用RevMan和综合荟萃分析程序进行统计分析。鉴于非洲阿拉伯人群的异质性，我们还根据种族进行了亚组分析。进行敏感性、异质性和发表偏倚分析以验证研究结果。这项荟萃分析包括862例T1DM病例以及1390例血糖正常对照，共包含十项比较。
我们的研究表明，DRB103（OR = 2.86）、DRB104（OR = 2.78）和DQB102（OR = 2.29）与T1DM风险增加呈正相关，而DRB107（OR = 0.48）、DRB111（OR = 0.20）、DRB113（OR = 0.47）、DRB115（OR = 0.30）、DQB105（OR = 0.39）和DQB1*06（OR = 0.27）与T1D呈负相关，表明对T1D有保护作用。
这项荟萃分析具有低异质性、敏感性和发表偏倚的特点，表明结果的稳健性和可靠性。
