Division of Neurology, Saitama Children's Medical Center, 2-1Shin-toshin, Chuou-ku, Saitama-city, Saitama 330-8777, Japan; Department of Pediatrics, Jikei University School of Medicine, 3-19-18Nishi-shinbashi, Minato-ku, Tokyo 105-8471, Japan.
Division of Neurology, Saitama Children's Medical Center, 2-1Shin-toshin, Chuou-ku, Saitama-city, Saitama 330-8777, Japan; Department for Child Health and Human Development, Saitama Children's Medical Center, 2-1Shin-toshin, Chuou-ku, Saitama-city, Saitama 330-8777, Japan.
Clin Neurophysiol. 2018 Sep;129(9):1920-1925. doi: 10.1016/j.clinph.2018.06.023. Epub 2018 Jul 6.
To determine whether the characteristics of scalp-recorded high frequency oscillations, especially ripples, can predict the "atypical forms" of benign epilepsy of childhood with centrotemporal spikes (ABECTS), in BECTS.
Seven patients with ABECTS and eighteen patients with BECTS underwent electroencephalography (EEG) in the secondary bilateral synchrony (SBS) and non-SBS periods for ABECTS patients. SBS period is that when more than 50% of the interictal epileptiform discharges (IEDs) are bilaterally synchronized. We determined the IED-ripple co-occurrence rate, performed time frequency analysis, and calculated the asymmetry index (AI).
The IEDs-ripple co-occurrence rate increased in the SBS compared to the non-SBS period. Time frequency analysis showed higher high-frequency activity rate and peak power in the SBS than in the non-SBS period. The AI was lower in ABECTS than BECTS, both in the non-SBS and SBS periods.
Ripples were enhanced in the SBS period of ABECTS, and bilaterally synchronized both in the non-SBS and SBS periods, whereas ripples in BECTS were localized unilaterally.
Bilaterally synchronized ripples in the non-SBS period of ABECTS may distinguish ABECTS from BECTS in the non-SBS period of IEDs, and may be helpful for early detection of progressive neurophysiological regression leading to early intervention.
确定头皮记录的高频振荡（尤其是棘波）的特征是否可以预测儿童良性癫痫伴中央颞区棘波（BECTS）中的“非典型形式”（ABECTS）。
七例 ABECTS 患者和十八例 BECTS 患者在继发性双侧同步（SBS）和非 SBS 期进行脑电图（EEG）检查。SBS 期是指当超过 50%的发作间期癫痫样放电（IED）双侧同步时。我们确定了 IED-棘波同时发生的比率，进行了时频分析，并计算了不对称指数（AI）。
与非 SBS 期相比，SBS 期的 IED-棘波同时发生率增加。时频分析显示 SBS 期的高频活动率和峰值功率高于非 SBS 期。非 SBS 和 SBS 期，ABECTS 的 AI 均低于 BECTS。
ABECTS 的 SBS 期棘波增强，并且在非 SBS 和 SBS 期均双侧同步，而 BECTS 的棘波则单侧局限。
ABECTS 非 SBS 期双侧同步棘波可能有助于区分 ABECTS 和 BECTS 在 IED 的非 SBS 期，并有助于早期检测导致早期干预的进行性神经生理退行性变。
