镰状细胞病孕妇中的趋化因子。

Chemokines in pregnant women with sickle cell disease.

机构信息

Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Rua dos Coelhos, 300, Boa Vista, 50.070-550 Recife, Pernambuco, Brazil; Fundação de Hematologia e Hemoterapia de Pernambuco HEMOPE, Rua Joaquim Nabuco, 171, Graças, 52.011-000 Recife, Pernambuco, Brazil; Universidade Federal de Pernambuco (UFPE), Av. Prof. Moraes Rego, 1235, Cidade Universitária, 50.670-90 Recife, Pernambuco, Brazil.

Fundação de Hematologia e Hemoterapia de Pernambuco HEMOPE, Rua Joaquim Nabuco, 171, Graças, 52.011-000 Recife, Pernambuco, Brazil.

出版信息

Cytokine. 2019 Jan;113:195-199. doi: 10.1016/j.cyto.2018.07.002. Epub 2018 Jul 10.

DOI:10.1016/j.cyto.2018.07.002

PMID:30006250

Abstract

Pregnancy in sickle cell disease is a problem due to the adverse outcomes related to the disease. Research into the role of chemokines in sickle cell disease is available, but studies investigating the disease in pregnancy are scarce. Our data show the chemokine profiles of pregnant women with sickle cell disease compared with control groups. There were no differences in MCP-1 level among the groups, but IL-8 and MIG were likely related with disease activity. In addition, levels of IP-10 were higher in pregnant women with sickle cell disease and, interestingly, RANTES levels were higher in normal pregnancy when compared to pregnancy in sickle cell disease. More studies should be encouraged to fully elucidate chemokine activity during pregnancy in sickle cell disease.

摘要

妊娠合并镰状细胞病是一个问题，因为与该疾病相关的不良结局。趋化因子在镰状细胞病中的作用的研究已经有了，但研究妊娠合并镰状细胞病的研究却很少。我们的数据显示了镰状细胞病孕妇与对照组的趋化因子谱。各组之间 MCP-1 水平没有差异，但 IL-8 和 MIG 可能与疾病活动有关。此外，妊娠合并镰状细胞病患者 IP-10 水平较高，有趣的是，与妊娠合并镰状细胞病相比，正常妊娠时 RANTES 水平较高。应该鼓励更多的研究来充分阐明妊娠期间镰状细胞病中趋化因子的活性。