Type 1 diabetes is associated with T-wave morphology changes. The Thousand & 1 Study.
作者信息
Isaksen Jonas L, Graff Claus, Ellervik Christina, Jensen Jan Skov, Andersen Henrik Ullits, Rossing Peter, Kanters Jorgen K, Jensen Magnus T
机构信息
Laboratory of Experimental Cardiology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.
Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.
出版信息
J Electrocardiol. 2018 Nov-Dec;51(6S):S72-S77. doi: 10.1016/j.jelectrocard.2018.05.015. Epub 2018 May 24.
BACKGROUND
Repolarization is impaired in patients with type 1 diabetes mellitus (T1DM), and repolarization disturbances are associated with an increased mortality. To study cardiac repolarization, we assessed T-wave morphology in patients with T1DM without known heart disease.
METHODS
855 T1DM patients without known heart disease were matched 1:2 with 1710 people from a background population. Rate-corrected T-wave morphology markers were obtained. Patients were stratified by albuminuria. Results are mean ± standard deviation.
RESULTS
T-waves were flatter (0.398 ± 0.059 vs. 0.382 ± 0.062, p < 0.001) and more asymmetric (0.082 ± 0.068 vs. 0.071 ± 0.084, p = 0.001) in T1DM. Patients with albuminuria had an increased heart rate (normoalbuminuria: 71 ± 13 bpm, microalbuminuria: 75 ± 12 bpm, p < 0.001, macroalbuminuria: 78 ± 12 bpm, p < 0.001) and more asymmetric T-waves (normoalbuminuria: 0.079 ± 0.060, microalbuminuria: 0.094 ± 0.085, p < 0.01, macroalbuminuria: 0.101 ± 0.080, p < 0.01), but the QTc interval remained unchanged.
CONCLUSIONS
T1DM is associated with changes in T-wave morphology. T-wave asymmetry but not QTc interval is associated with albuminuria in T1DM and may be used for stratification.
Zotero 插件