手性超分子配位笼作为高效的淀粉样β聚集抑制剂。
Chiral supramolecular coordination cages as high-performance inhibitors against amyloid-β aggregation.
机构信息
Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China.
出版信息
Chem Commun (Camb). 2018 Aug 2;54(63):8725-8728. doi: 10.1039/c8cc04913k.
PMID:30024578
Abstract
Four pairs of chiral supramolecular coordination cages were facilely synthesized, and they could efficiently inhibit amyloid-β (Aβ) aggregation with a high inhibition rate of 0.64-0.86. This research provides a new perspective on the design of chiral Aβ inhibitors using supramolecular metal-organic cages.
摘要
四对手性超分子配位笼被简便地合成出来，它们能够高效地抑制淀粉样β（Aβ）聚集，抑制率高达 0.64-0.86。这项研究为使用超分子金属有机笼设计手性 Aβ抑制剂提供了新的视角。
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