一种用于安全有效癌症治疗的多核共递药系统的新颖设计。
A novel design of a polynuclear co-delivery system for safe and efficient cancer therapy.
机构信息
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.
出版信息
Chem Commun (Camb). 2018 Aug 14;54(63):8737-8740. doi: 10.1039/c8cc03720e. Epub 2018 Jul 20.
We report a novel and easy-to-fabricate polynuclear nanoparticle based on the collaborative re-assembly of nanoparticles as a robust chemogene co-delivery platform. Specifically, the polynuclear nanoparticle carrying DOX and siBcl-2 exerts remarkable co-delivery efficiency, increases tumour cell apoptosis and inhibits tumour cell proliferation in vitro and in vivo.
我们报道了一种新颖且易于制备的基于纳米粒子协同再组装的多核纳米粒子，作为一种稳健的化学基因共递药平台。具体而言，载有 DOX 和 siBcl-2 的多核纳米粒子在体外和体内均表现出显著的共递药效率，增加了肿瘤细胞凋亡并抑制了肿瘤细胞增殖。
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