Suzdak P D, Gianutsos G
J Neural Transm. 1985;64(3-4):163-72. doi: 10.1007/BF01256464.
Treatment of mice with DSP4 (a neurotoxin that abolishes the presynaptic noradrenergic neuron; Dooley et al., 1983) resulted in: (A) a decrease in the Bmax for the low affinity GABA-B receptor site in the cerebral cortex and hippocampus, whereas the Bmax for the high affinity GABA-B receptor site was unaffected; (B) a greater potentiation of norepinephrine stimulated adenylate cyclase by baclofen in cerebral cortex slices; and (C) a decrease in the Bmax for both the high and low affinity GABA-A receptor sites in the cerebral cortex and hippocampus. These data, coupled with previous work from our laboratory, suggest that the GABA-B receptor may be associated with both the noradrenergic nerve terminal and the post-synaptic neuron receiving noradrenergic input, whereas the GABA-A receptor may be associated with the noradrenergic nerve terminal. These data further suggest a functional coupling between the noradrenergic and GABA-ergic systems.
用DSP4（一种能消除突触前去甲肾上腺素能神经元的神经毒素；Dooley等人，1983年）处理小鼠后，结果如下：（A）大脑皮层和海马体中低亲和力GABA-B受体位点的Bmax降低，而高亲和力GABA-B受体位点的Bmax未受影响；（B）在大脑皮层切片中，巴氯芬对去甲肾上腺素刺激的腺苷酸环化酶的增强作用更大；（C）大脑皮层和海马体中高亲和力和低亲和力GABA-A受体位点的Bmax均降低。这些数据，再加上我们实验室之前的研究工作，表明GABA-B受体可能与去甲肾上腺素能神经末梢以及接受去甲肾上腺素能输入的突触后神经元相关联，而GABA-A受体可能与去甲肾上腺素能神经末梢相关联。这些数据进一步表明去甲肾上腺素能系统和GABA能系统之间存在功能耦合。
