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2008 - 2012年波兰北部儿科人群抗精神病药物处方趋势

Antipsychotic Medication Prescribing Trends in a Pediatric Population in Northern Poland 2008-2012.

作者信息

Waszak Przemysław M, Zagożdżon Paweł, Pierucka Magdalena, Kubanek Alicja

机构信息

1 Department of Hygiene and Epidemiology, Medical University of Gdansk , Gdansk, Poland .

2 Department of Developmental Psychiatry, Psychotic and Geriatric Disorders, Medical University of Gdansk , Gdansk, Poland .

出版信息

J Child Adolesc Psychopharmacol. 2018 Nov;28(9):631-636. doi: 10.1089/cap.2017.0154. Epub 2018 Jul 26.

Abstract

OBJECTIVES

In recent years antipsychotics have been increasingly used in the population of children and adolescents. The objective of this article is to profile the use of antipsychotic medications in a pediatric population in Poland based on data from the Pomeranian region (Northern Poland).

METHODS

The study was based on National Health Fund data about prescription drug reimbursement between 2008 and 2012. A patient database was created using ID to analyze specific patterns and information about individuals using antipsychotics. Percentage population indicators were calculated using official demographic reports.

RESULTS

An increased number of overall prescriptions was observed since 2008, with a subsequent decline to its lowest number in 2012. The population with at least one antipsychotic-filled prescription per year has grown in the same time. The annual rate has increased from 0.26% to 0.31% of the general population between 0 and 17 years of age in the Pomeranian region. We observed an increasing number of females and the 0- to 4-year-old receiving antipsychotic prescriptions. The population share of prescribed first-generation antipsychotics exceeded the share of second-generation antipsychotics (SGAs). The use of SGAs increased from 38% to 44% of all prescriptions, during the observation period. The most frequently prescribed drugs were Risperidone (26.7%) and Chlorprothixene (21.7%).

CONCLUSIONS

The study revealed that the prescribing patterns of antipsychotics increased in the Polish pediatric population and concerned more patients from the youngest group. The high prevalence of such early exposure to antipsychotics should focus more attention on drug safety in this population.

摘要

目的

近年来,抗精神病药物在儿童和青少年人群中的使用越来越多。本文的目的是根据波兰北部波美拉尼亚地区的数据,概述波兰儿科人群中抗精神病药物的使用情况。

方法

该研究基于国家卫生基金2008年至2012年期间有关处方药报销的数据。使用身份证创建了一个患者数据库,以分析使用抗精神病药物的个体的特定模式和信息。使用官方人口统计报告计算人口百分比指标。

结果

自2008年以来,总体处方数量有所增加,随后在2012年降至最低水平。同时,每年至少有一张抗精神病药物处方的人群有所增加。在波美拉尼亚地区,0至17岁的普通人群中,这一比例从0.26%增至0.31%。我们观察到接受抗精神病药物处方的女性和0至4岁儿童的数量在增加。第一代抗精神病药物的处方人群比例超过了第二代抗精神病药物(SGA)。在观察期内,SGA的使用量从所有处方的38%增至44%。最常开具的药物是利培酮(26.7%)和氯普噻吨(21.7%)。

结论

该研究表明,波兰儿科人群中抗精神病药物的处方模式有所增加,且涉及最年轻群体的更多患者。如此早地接触抗精神病药物的高发生率应使人们更加关注该人群的药物安全性。

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