通过转移氢化中间体的捕获实现手性炔烃的卤氢加成反应。
Stereoselective Alkyne Hydrohalogenation by Trapping of Transfer Hydrogenation Intermediates.
机构信息
Institut für Chemie , Technische Universität Berlin , Strasse des 17. Juni 115 , 10623 Berlin , Germany.
出版信息
Org Lett. 2018 Aug 17;20(16):4926-4929. doi: 10.1021/acs.orglett.8b02055. Epub 2018 Jul 31.
PMID:30062890
Abstract
A catalytically generated vinylcopper complex, the reactive intermediate of a copper(I)-catalyzed alkyne transfer hydrogenation, can be trapped by commercially available halogen electrophiles. In this manner, internal alkynes can stereoselectively be hydrohalogenated to the corresponding vinyl chlorides, bromides, and iodides.
摘要
一种催化生成的乙烯基铜络合物，是铜（I）催化炔烃转移氢化的反应中间体，可以被市售的卤代亲电试剂捕获。通过这种方式，内部炔烃可以立体选择性地氢卤化得到相应的乙烯基氯、溴和碘化物。
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