人胎儿胃腺中的血管活性肠肽和组胺H2受体活性
VIP and histamine H2 receptor activity in human fetal gastric glands.
作者信息
Emami S, Chastre E, Mulliez N, Gonzales M, Gespach C
出版信息
Experientia. 1986 Apr 15;42(4):423-5. doi: 10.1007/BF02118640.
Vasoactive intestinal peptide (VIP, EC50 = 6.4 X 10(-10)M) and histamine (EC50 = 3 X 10(-6)M) activated the cyclic AMP generating system in gastric glands isolated from two human fetuses at 23 weeks gestation. Histamine antagonism by the H2 receptor blockers cimetidine (Ki = 0.35 X 10(-6)M) and ranitidine (ki = 0.51 X 10(-7)M) clearly characterized the histaminic activation as being of the H2 type. It is suggested that these two vasoactive hormones may operate as neurocrine/paracrine regulators of the differentiation and/or function of the human gastric mucosa in utero.
血管活性肠肽（VIP，半数有效浓度[EC50]=6.4×10⁻¹⁰M）和组胺（EC50 = 3×10⁻⁶M）激活了从两名妊娠23周的人类胎儿分离出的胃腺中的环磷酸腺苷生成系统。H2受体阻滞剂西咪替丁（抑制常数[Ki]=0.35×10⁻⁶M）和雷尼替丁（Ki = 0.51×10⁻⁷M）对组胺的拮抗作用明确表明组胺激活属于H2型。提示这两种血管活性激素可能作为神经分泌/旁分泌调节因子，对子宫内人类胃黏膜的分化和/或功能起作用。
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