Reale V, Evans P D, Villegas J
J Exp Biol. 1986 Mar;121:421-43. doi: 10.1242/jeb.121.1.421.
The actions of octopamine on the Schwann cells of the giant nerve fibre of the tropical squid are described. The pharmacology of the receptors mediating the actions of octopamine has been investigated in terms of stereospecificity, amine specificity and interactions with a range of agonists and antagonists. The receptors are maximally activated by D(-)-octopamine and share many of the characteristics of OCTOPAMINE2 class receptors in other preparations. The octopamine receptors appear to mediate their actions by increasing the intracellular levels of cyclic AMP in the Schwann cells. Low concentrations of octopamine potentiate the actions of the nicotinic cholinergic activation system of the Schwann cells. The results are discussed in terms of the possible physiological role of octopamine in the modulation of Schwann cell activity during stressful conditions when the giant axon system is likely to be used at a high frequency to facilitate the escape response of the squid.
本文描述了章鱼胺对热带鱿鱼巨大神经纤维施万细胞的作用。已从立体特异性、胺特异性以及与一系列激动剂和拮抗剂的相互作用方面研究了介导章鱼胺作用的受体的药理学特性。这些受体被D(-)-章鱼胺最大程度激活，并且在其他制剂中具有许多OCTOPAMINE2类受体的特征。章鱼胺受体似乎通过增加施万细胞内的环磷酸腺苷水平来介导其作用。低浓度的章鱼胺可增强施万细胞烟碱型胆碱能激活系统的作用。本文从章鱼胺在应激条件下调节施万细胞活性时可能发挥的生理作用方面进行了讨论，在应激条件下，巨大轴突系统可能会被高频使用以促进鱿鱼的逃避反应。
