The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Hainan General Hospital, Haikou, Hainan, China.
CNS Neurosci Ther. 2018 Dec;24(12):1089-1099. doi: 10.1111/cns.13045. Epub 2018 Aug 3.
Parkinson's disease (PD) is a common degenerative neurological disease leading to a series of familial, medical, and social problems. Although it is known that the major characteristics of PD pathophysiology are the dysfunction of basal ganglia due to injury/loss of dopaminergic neurons in the substantia nigra pars compacta dopaminergic and exhaustion of corpus striatum dopamine, therapeutic modalities for PD are limited in clinical settings up to date. It is of utmost importance to better understand PD pathophysiology and explore new solutions for this serious neurodegenerative disorder. Our recent work and those of others suggest that the delta-opioid receptor (DOR) is neuroprotective and serves an antiparkinsonism role in the brain. This review summarizes recent progress in this field and explores potential mechanisms for DOR-mediated antiparkinsonism.
帕金森病(PD)是一种常见的退行性神经疾病,导致一系列家族性、医学和社会问题。尽管已知 PD 病理生理学的主要特征是由于黑质致密部多巴胺能神经元损伤/缺失导致基底节功能障碍和纹状体多巴胺耗竭,但迄今为止,PD 的治疗方法在临床实践中仍很有限。更好地了解 PD 病理生理学并探索这种严重神经退行性疾病的新解决方案至关重要。我们最近的工作和其他人的工作表明,δ-阿片受体(DOR)具有神经保护作用,并在大脑中发挥抗帕金森作用。本综述总结了该领域的最新进展,并探讨了 DOR 介导的抗帕金森作用的潜在机制。