Summers Mathew J, Rainero Innocenzo, Vercelli Alessandro E, Aumayr Georg, de Rosario Helios, Mönter Michaela, Kawashima Ryuta
Sunshine Coast Mind and Neuroscience - Thompson Institute, University of the Sunshine Coast, Queensland, Australia.
Aging, Brain and Memory Clinic, Department of Neuroscience, University of Torino, Italy.
Alzheimers Dement (N Y). 2018 Jul 10;4:252-262. doi: 10.1016/j.trci.2018.06.004. eCollection 2018.
Frailty increases the risk of poor health outcomes, disability, hospitalization, and death in older adults and affects 7%-12% of the aging population. Secondary impacts of frailty on psychological health and socialization are significant negative contributors to poor outcomes for frail older adults.
The My Active and Healthy Aging (My-AHA) consortium has developed an information and communications technology-based platform to support active and healthy aging through early detection of prefrailty and provision of individually tailored interventions, targeting multidomain risks for frailty across physical activity, cognitive activity, diet and nutrition, sleep, and psychosocial activities. Six hundred adults aged 60 years and older will be recruited to participate in a multinational, multisite 18-month randomized controlled trial to test the efficacy of the My-AHA platform to detect prefrailty and the efficacy of individually tailored interventions to prevent development of clinical frailty in this cohort. A total of 10 centers from Italy, Germany, Austria, Spain, United Kingdom, Belgium, Sweden, Japan, South Korea, and Australia will participate in the randomized controlled trial.
Pilot testing (Alpha Wave) of the My-AHA platform and all ancillary systems has been completed with a small group of older adults in Europe with the full randomized controlled trial scheduled to commence in 2018.
The My-AHA study will expand the understanding of antecedent risk factors for clinical frailty so as to deliver targeted interventions to adults with prefrailty. Through the use of an information and communications technology platform that can connect with multiple devices within the older adult's own home, the My-AHA platform is designed to measure an individual's risk factors for frailty across multiple domains and then deliver personalized domain-specific interventions to the individual. The My-AHA platform is technology-agnostic, enabling the integration of new devices and sensor platforms as they emerge.
衰弱会增加老年人健康状况不佳、残疾、住院和死亡的风险，影响7%-12%的老年人口。衰弱对心理健康和社交的继发性影响是衰弱老年人不良结局的重要负面因素。
“我的积极健康老龄化”（My-AHA）联盟开发了一个基于信息通信技术的平台，通过早期检测衰弱前期并提供个性化干预措施，针对身体活动、认知活动、饮食与营养、睡眠以及心理社会活动等多领域的衰弱风险，来支持积极健康老龄化。将招募60岁及以上的600名成年人参与一项为期18个月的多国多中心随机对照试验，以测试My-AHA平台检测衰弱前期的效果以及个性化干预措施预防该队列中临床衰弱发生的效果。来自意大利、德国、奥地利、西班牙、英国、比利时、瑞典、日本、韩国和澳大利亚的10个中心将参与该随机对照试验。
My-AHA平台及所有辅助系统的试点测试（阿尔法波）已在欧洲一小群老年人中完成，全面随机对照试验计划于2018年开始。
My-AHA研究将扩展对临床衰弱前期危险因素的认识，以便为衰弱前期成年人提供有针对性的干预措施。通过使用一个可与老年人自己家中的多个设备连接的信息通信技术平台，My-AHA平台旨在测量个体在多个领域的衰弱危险因素，然后为个体提供个性化的特定领域干预措施。My-AHA平台与技术无关，能够在新设备和传感器平台出现时进行整合。
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