Bronckers Inge M G J, van Geel Maartje J, van de Kerkhof Peter C M, de Jong Elke M G J, Seyger Marieke M B
a Department of Dermatology , Radboud University Medical Center , Nijmegen , The Netherlands.
J Dermatolog Treat. 2019 May;30(3):208-215. doi: 10.1080/09546634.2018.1506077. Epub 2018 Sep 7.
Psoriasis can have a substantial impact on health-related quality of life (HRQoL), life course, and work productivity. Young adulthood is a critical, sensitive period of development that includes major life changing decisions. The impact of psoriasis on this vulnerable population is yet unknown.
To assess QoL, life course, and work productivity in young adults with psoriasis and identify characteristics influencing these patient-reported outcomes (PRO).
An explorative, cross-sectional study was performed in psoriasis patients aged 18-30 years. Individuals completed a set of questionnaires regarding their health status (DLQI, SF-36, EQ-5D), achievement of developmental milestones (COLQ), and work productivity (WPAI-PSO, PRODISQ).
Seventy-five patients (22 males, 53 females; median age [IQR], 21.0 [8.0]). Median PASI and BSA, respectively, were 4.4 [4.9] and 4.5 [8.4]. Young adults experienced feelings of embarrassment, impairments in physical health and work productivity, and difficulties in social development. Patients with more severe psoriasis, longer disease duration, higher body mass index (BMI), female patients and patients closer to their thirties tended to be more affected.
In the young adult psoriasis population, substantial QoL impairments were found. Female patients, patients with high BMI, or long disease duration in particular tended to experience more difficulties. These exploratory findings indicate the need for further studies in young adults to detect potential clinical predictors for severe HRQoL impairments.
银屑病可对健康相关生活质量（HRQoL）、生命历程和工作效率产生重大影响。青年期是一个关键且敏感的发育阶段，包含重大的人生决策。银屑病对这一脆弱人群的影响尚不清楚。
评估银屑病青年患者的生活质量、生命历程和工作效率，并确定影响这些患者报告结局（PRO）的特征。
对18 - 30岁的银屑病患者进行了一项探索性横断面研究。研究对象完成了一组关于其健康状况（皮肤病生活质量指数[DLQI]、36项简短健康调查[SF - 36]、欧洲五维度健康量表[EQ - 5D]）、发育里程碑达成情况（COLQ）和工作效率（银屑病工作效率和活动指数[WPAI - PSO]、PRODISQ）的问卷。
75例患者（22例男性，53例女性；年龄中位数[四分位间距]，21.0[8.0]）。银屑病面积和严重程度指数（PASI）和体表面积（BSA）中位数分别为4.4[4.9]和4.5[8.4]。青年患者有尴尬感，身体健康和工作效率受损，社会发展存在困难。银屑病更严重、病程更长、体重指数（BMI）更高的患者、女性患者以及年龄更接近30岁的患者受影响往往更大。
在银屑病青年患者群体中，发现了严重的生活质量受损情况。特别是女性患者、BMI高的患者或病程长的患者往往经历更多困难。这些探索性研究结果表明，需要对青年患者进行进一步研究，以发现严重HRQoL受损的潜在临床预测因素。
