Department of Neurosurgery, Sapporo Medical University, Sapporo, Japan.
Department of Neurosurgery, Sapporo Medical University, Sapporo, Japan.
Clin Neurophysiol. 2018 Oct;129(10):2132-2136. doi: 10.1016/j.clinph.2018.07.014. Epub 2018 Aug 1.
This study investigated the function and networks of the auditory cortices in the posterior lateral superior temporal area (PLST) using a combination of electrical cortical stimulation and diffusion tensor imaging (DTI).
Seven patients with intractable focal epilepsy in which the PLST auditory cortices were identified during the electrical cortical stimulation were enrolled in this study (left side: four patients, right side: three patients). Electrical stimulation at 50 Hz was applied to the chronically implanted subdural electrodes to identify the PLST auditory cortices. DTI was used to identify the subcortical fibers originating from the PLST auditory cortices found by electrical stimulation.
Electrical stimulation of the right PLST auditory cortices induced hearing impairment in three patients and left side stimulation elicited hearing illusory sounds in four patients. DTI detected the middle longitudinal fasciculus (MLF) in all patients, the superior longitudinal fasciculus (SLF) in six patients and the inferior fronto-occipital fasciculus (IFOF) in three patients, originating from the PLST auditory cortices.
This study suggests different functional roles between the right and left PLST auditory cortices, and the networks originating from these areas.
MLF, SLF and IFOF might be associated with the auditory processing.
本研究采用电皮质刺激和弥散张量成像（DTI）相结合的方法，研究了后外侧上颞区（PLST）听觉皮质的功能和网络。
本研究纳入了 7 例在电皮质刺激过程中确定了 PLST 听觉皮质的难治性局灶性癫痫患者（左侧：4 例，右侧：3 例）。用 50Hz 的电刺激施加于慢性植入的硬脑膜下电极以确定 PLST 听觉皮质。DTI 用于识别由电刺激发现的源自 PLST 听觉皮质的皮质下纤维。
右侧 PLST 听觉皮质的电刺激导致 3 例患者听力受损，左侧刺激引起 4 例患者听觉幻觉。DTI 在所有患者中均检测到了发自 PLST 听觉皮质的正中纵束（MLF），在 6 例患者中检测到了上纵束（SLF），在 3 例患者中检测到了下额枕束（IFOF）。
本研究提示了左右 PLST 听觉皮质以及源自这些区域的网络具有不同的功能作用。
MLF、SLF 和 IFOF 可能与听觉处理有关。
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