Avoli M
Brain Res. 1986 Apr 2;370(1):165-70. doi: 10.1016/0006-8993(86)91118-2.
Neocortical neurons in slices of the rat sensorimotor region maintained in vitro generate postsynaptic potentials (PSPs) in response to focal extracellular stimulation. These PSPs are mainly depolarizing at the resting membrane potential (Vm) but a sequence of depolarizing-hyperpolarizing potentials is often disclosed by depolarizing the Vm. The stimulus-induced hyperpolarization can last up to 1000 ms and show two components: the early one (peak latency 10-20 ms), is inverted by diffusion of Cl- into the cell; the late one is diminished by augmenting [K+]o. The membrane conductance is increased throughout the stimulus-induced hyperpolarization, mainly during the first 10-60 ms. A decrease in excitability results from both the hyperpolarizing trend and the conductance increase. The latter is more effective in decreasing depolarizing than hyperpolarizing pulses of current injected intracellularly.
在体外维持的大鼠感觉运动区切片中的新皮质神经元，在受到局部细胞外刺激时会产生突触后电位（PSP）。这些PSP在静息膜电位（Vm）时主要是去极化的，但通过使Vm去极化，常常会揭示出一系列去极化-超极化电位。刺激诱导的超极化可持续长达1000毫秒，并显示出两个成分：早期成分（峰值潜伏期10 - 20毫秒），通过Cl-扩散进入细胞而反转；晚期成分通过增加[K+]o而减弱。在整个刺激诱导的超极化过程中，膜电导增加，主要在最初的10 - 60毫秒内。超极化趋势和电导增加都会导致兴奋性降低。后者在降低细胞内注入的去极化电流脉冲方面比超极化电流脉冲更有效。
