Zotova T Yu, Blagonravov M L, Lapaev N N, Denisova A P
V. A. Frolov Department of General Pathology and Pathological Physiology, Medical Institute, Russian University of Peoples' Friendship, Moscow, Russia.
Bull Exp Biol Med. 2018 Aug;165(4):440-444. doi: 10.1007/s10517-018-4189-4. Epub 2018 Aug 18.
We analyzed diurnal hemodynamic parameters (HR, systolic BP, and diastolic BP) recorded from two groups of edematous and preeclamptic pregnant women. The unidirectional character of changes in the control over the functional state of cardiovascular system was revealed except for the indices, which mark a pathological process: elevated diurnal BP in preeclampsia and diminished percentage of oscillation power in edematous patients. Uniformity of the regulatory changes in patients with and without arterial hypertension can be viewed as manifestation of allostasis developed by the cardiovascular system during pregnancy. In preeclampsia, the greater allostatic load was reflected by the changes in diurnal, daytime, and nighttime BP and in the circadian index calculated for HR, systolic BP, and diastolic BP. In edematous patients, elevation of allostatic load was indicated by the percentage of ultradian rhythms.
我们分析了两组水肿型和先兆子痫孕妇记录的昼夜血流动力学参数(心率、收缩压和舒张压)。除了标志着病理过程的指标外,揭示了心血管系统功能状态控制变化的单向特征:先兆子痫患者昼夜血压升高,水肿患者振荡功率百分比降低。有和没有动脉高血压患者调节变化的一致性可视为孕期心血管系统产生的同态调节的表现。在先兆子痫中,昼夜、白天和夜间血压的变化以及根据心率、收缩压和舒张压计算的昼夜节律指数的变化反映了更大的同态调节负荷。在水肿患者中,超日节律百分比表明同态调节负荷增加。