接受双重分化剂治疗的急性早幼粒细胞白血病患者的侵袭性真菌感染：真实世界数据
Invasive Fungal Infections in Acute Promyelocytic Leukemia on Dual Differentiating Agents: Real World Data.
作者信息
Yanamandra Uday, Karunakaran Parathan, Khadwal Alka, Prakash Gaurav, Lad Deepesh, Naseem Shano, Varma Neelam, Chakrabarti Arunaloke, Varma Subhash, Malhotra Pankaj
机构信息
1Department of Haematology and Stem Cell Transplant, Army Hospital (Research and Referral), Delhi, 110010 India.
2Department of Internal Medicine and Clinical Hematology, P.G.I.M.E.R, Chandigarh, U.T 160012 India.
出版信息
Indian J Hematol Blood Transfus. 2018 Jul;34(3):466-468. doi: 10.1007/s12288-017-0894-9. Epub 2017 Oct 26.
Invasive fungal infection (IFI) in patients with acute promyelocytic leukemia (APL) is a common phenomenon in developing countries. In a systematic study (Dual Inducing Differentiating agents-Indian Trial: DID-IT) using dual differentiating agents (ATO and ATRA) in 98 APL patients at our center we report 18.3% incidence of IFI (n-18). Among all cases of IFI three were definitive, 14 were probable and one was possible IFI. We conclude that incidence of IFI in APL is affected by environmental and therapy related factors and mere usage of dual differentiating agents need not necessarily decrease the incidence of fungal infections.
在发展中国家，急性早幼粒细胞白血病（APL）患者发生侵袭性真菌感染（IFI）是一种常见现象。在我们中心对98例APL患者使用双诱导分化剂（ATO和ATRA）进行的一项系统研究（双诱导分化剂-印度试验：DID-IT）中，我们报告IFI的发生率为18.3%（n = 18）。在所有IFI病例中，3例为确诊病例，14例为很可能病例，1例为可能病例。我们得出结论，APL中IFI的发生率受环境和治疗相关因素影响，单纯使用双诱导分化剂不一定能降低真菌感染的发生率。
Zotero 插件