Mühler Roland, Petzke Alexandra, Verhey Jesko L
Department of Experimental Audiology, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.
Eur Arch Otorhinolaryngol. 2018 Oct;275(10):2601-2605. doi: 10.1007/s00405-018-5097-y. Epub 2018 Aug 21.
The purpose of this study was to establish a paradigm that allows for the simultaneous recording of auditory steady-state responses (ASSRs) to two largely different modulation rates.
In 21 normal-hearing adults, ASSRs for 40- and 80-Hz modulation rates were recorded in (1) a classical monotic single-stimulus condition, (2) a monotic simultaneous condition, where 40 Hz was paired with a 1-kHz carrier and 80 Hz with a 2-kHz carrier, and (3) a dichotic simultaneous condition with the same modulation rate/carrier pairing. Response amplitudes, residual noises, and signal-to-noise ratios were compared across conditions.
Whereas the multiple-stimulus paradigms reduced the 40-Hz ASSR amplitude compared to the single condition, there was hardly any change for the 80-Hz ASSR. In all conditions, the 40-Hz ASSR was considerably larger than the 80-Hz ASSR. The residual noise was only 1.4 times larger for 40 Hz than for the 80 Hz.
The proposed procedure using multiple stimuli with largely different modulation rates can be used to study differences in their responses and residual noise under identical states of vigilance. The amplitude reduction caused by the interaction between multiple stimuli has to be taken into account when interpreting the results.
本研究的目的是建立一种范式，以便能够同时记录对两种差异较大调制率的听觉稳态反应（ASSR）。
在21名听力正常的成年人中，分别在以下三种条件下记录40赫兹和80赫兹调制率的ASSR：（1）经典单耳单刺激条件；（2）单耳同时刺激条件，即40赫兹与1千赫兹载波配对，80赫兹与2千赫兹载波配对；（3）双耳同时刺激条件，调制率/载波配对相同。比较不同条件下的反应幅度、残余噪声和信噪比。
与单刺激条件相比，多刺激范式降低了40赫兹ASSR的幅度，但80赫兹ASSR几乎没有变化。在所有条件下，40赫兹ASSR均显著大于80赫兹ASSR。40赫兹的残余噪声仅比80赫兹大1.4倍。
所提出的使用具有较大不同调制率的多刺激程序可用于研究在相同警觉状态下它们的反应和残余噪声的差异。在解释结果时必须考虑多刺激之间相互作用引起的幅度降低。
