Buelvas-Jiménez Neudo, Suárez-Useche Raibel J, Vielma-Guevara José R
Lic. Biología. M.Sc. en Biología Celular. Laboratorio de Inmunobiología, Centro de Investigaciones Biomédicas (CIB), Instituto Venezolano de Investigaciones Científicas (IVIC), Hospital Universitario de Maracaibo. Maracaibo, Venezuela.
Lic. Bioanálisis. M. Sc. en Biología Molecular. Laboratorio de Inmunobiología, Centro de Investigaciones Biomédicas (CIB), Instituto Venezolano de Investigaciones Científicas (IVIC), Hospital Universitario de Maracaibo. Maracaibo, Venezuela.
Rev Salud Publica (Bogota). 2017 Jan-Feb;19(1):118-122. doi: 10.15446/rsap.v19n1.54415.
To determine if considering inflammasome NLRP3 as a treatment option for kidney disease is possible.
Literature review related to NLRP3 inflammasome structure, biological function and relationship with renal disease and others (hypertension, diabetes, gout, atherosclerosis, amyloidosis, Alzheimer's disease); the systematic review was made searching in the databases PubMed and SciELO for the following terms: "The NLRP3 inflammasome therapeutic for kidney disease", "NLRP3 nflammasome in kidney disease" in PubMed, and "Inflammasome" for Scielo.
146 documents were found, althoughonly 34 matched the working hypothesis concerning the NLRP3 inflammasome as a central component of various diseases in humans, with potential therapeutic use. The NLRP3 inflammasome is responsible for the maturation of inflammatory pro-interleukin IL-1 β and IL-18, which can be triggered by aggregated or crystalline materials (particles), and by various microorganisms and toxins derived from these; however, the way how activation mechanisms work is not completely clear.
Research on new therapies that focus on removing or inhibiting inflammasome components, both individually and together, is proposed.
确定将炎性小体NLRP3作为肾脏疾病的一种治疗选择是否可行。
对与NLRP3炎性小体结构、生物学功能以及与肾脏疾病及其他疾病（高血压、糖尿病、痛风、动脉粥样硬化、淀粉样变性、阿尔茨海默病）的关系相关的文献进行综述；通过在PubMed和SciELO数据库中检索以下术语进行系统综述：PubMed中的“The NLRP3 inflammasome therapeutic for kidney disease”“NLRP3 nflammasome in kidney disease”，以及Scielo中的“Inflammasome”。
共找到146篇文献，尽管只有34篇与关于NLRP3炎性小体作为人类多种疾病的核心成分且具有潜在治疗用途的工作假设相符。NLRP3炎性小体负责炎性前白细胞介素IL-1β和IL-18的成熟，其可由聚集或结晶物质（颗粒）以及各种微生物和源自这些的毒素触发；然而，激活机制的工作方式尚不完全清楚。
建议开展针对单独或共同去除或抑制炎性小体成分的新疗法的研究。
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