癌症模型中食管疾病的系列内镜评估：食管腺癌（EAC）药物发现与开发的范式转变

Serial Endoscopic Evaluation of Esophageal Disease in a Cancer Model: A Paradigm Shift for Esophageal Adenocarcinoma (EAC) Drug Discovery and Development.

作者信息

Omstead Ashten N, Kosovec Juliann E, Matsui Daisuke, Martin Samantha A, Smith Matthew A, Aaron Guel D, Kolano Jenna, Komatsu Yoshihiro, Habib Fahim, Lai Christopher, Christopher Kevi, Kelly Ronan J, Zaidi Ali H, Jobe Blair A

机构信息

a Esophageal and Lung Institute , Allegheny Health Network , Pittsburgh , PA , USA.

b Department of Gastroenterological Surgery , Kanazawa University Hospital , Kanazawa , Ishikawa , Japan.

出版信息

Cancer Invest. 2018;36(7):363-370. doi: 10.1080/07357907.2018.1499029. Epub 2018 Aug 24.

DOI:10.1080/07357907.2018.1499029

PMID:30142016

Abstract

A rat model of surgically induced reflux recapitulates the development and progression of human esophageal adenocarcinoma (EAC). In this study, reflux was induced in rats followed by postoperative endoscopy with biopsy, to diagnose and monitor disease progression. Overall, percentage agreement between visual endoscopy and gold standard histology was 95%, with disease-specific classification accuracies of 100% and 75% for Barrett's with dysplasia and EAC, respectively. Additionally, the percentage agreement for biopsy in tumors >4 mm was 75%. Thereby, establishing endoscopic evaluation as a reliable tool to assess disease progression and provide biopsies for downstream correlates in a de novo EAC model.

摘要

手术诱导反流的大鼠模型概括了人类食管腺癌（EAC）的发展和进程。在本研究中，对大鼠进行反流诱导，随后进行术后内镜检查及活检，以诊断和监测疾病进展。总体而言，视觉内镜检查与金标准组织学之间的百分比一致性为95%，巴雷特食管伴发育异常和EAC的疾病特异性分类准确率分别为100%和75%。此外，肿瘤>4毫米时活检的百分比一致性为75%。从而，在内生性EAC模型中，将内镜评估确立为评估疾病进展并为下游关联因素提供活检样本的可靠工具。