Kavaliers M, Hirst M
Neurobiol Aging. 1986 May-Jun;7(3):179-83. doi: 10.1016/0197-4580(86)90040-0.
Day-night rhythms in feeding behavior and response to the putative sigma opiate agonist, N-allylnormetazocine (+/- SKF-10,047, 0.10-10 mg/kg), were measured in young (1-2 months), mature (8-12 months) and old (24-30 months) male CF-1 mice. The mice consumed more food at night than in the day-time, though this nocturnal peak was markedly reduced in the mature and old animals. The young mice also displayed a significant nocturnal enhancement in SKF-10,047 (0.10-1.0 mg/kg) stimulated feeding, that could, in part, be suppressed by the opiate antagonist naloxone (1.0 mg/kg). The day-night rhythm in ingestive responses to SKF-10,047 (0.10-1.0 mg/kg) was reduced in the mature animals and absent in the old animals. The old mice failed to show any significant increase in ingestive response following opiate administration. A higher dose of SKF-10,047 (10 mg/kg) had no significant ingestive effects in any of the age groups of mice; the excitatory, psychotomimetic-related effects, being also reduced in the old animals.
在年轻（1 - 2个月）、成熟（8 - 12个月）和老年（24 - 30个月）雄性CF - 1小鼠中，测量了进食行为的昼夜节律以及对假定的σ阿片受体激动剂N - 烯丙基去甲左啡诺（±SKF - 10,047，0.10 - 10毫克/千克）的反应。小鼠夜间进食量比白天多，不过在成熟和老年动物中，这种夜间进食高峰明显降低。年轻小鼠对SKF - 10,047（0.10 - 1.0毫克/千克）刺激的进食也表现出显著的夜间增强，部分可被阿片拮抗剂纳洛酮（1.0毫克/千克）抑制。成熟动物对SKF - 10,047（0.10 - 1.0毫克/千克）摄入反应的昼夜节律降低，老年动物则不存在这种节律。老年小鼠在给予阿片类药物后未表现出任何显著的摄入反应增加。更高剂量的SKF - 10,047（10毫克/千克）对任何年龄组的小鼠均无显著的摄入影响；在老年动物中，与兴奋、拟精神病相关的效应也有所降低。
