Wiesner J B, Moss R L
Pharmacol Biochem Behav. 1986 May;24(5):1235-9. doi: 10.1016/0091-3057(86)90177-2.
Open field behavior was observed in conjunction with mating behavior to discern whether the effect of intraventricular (ICV) beta-endorphin (beta-END) on sexual behavior may be secondary to akinesia. Three groups of ovariectomized, estrogen-progesterone-primed rats each received counterbalanced treatments of saline ICV, 2 micrograms beta-END ICV, or 2 micrograms beta-END ICV in combination with a selective opioid receptor antagonist. Receptive behavior (lordosis) and proceptive behaviors (presentation and ear wiggling) were consistently suppressed by beta-END, while ambulation was unaffected. Rearing and grooming were generally decreased, although this effect was statistically significant in only one experiment. Pretreatment with the mu-1 antagonist naloxazone (50 mg/kg intravenously) reversed the effects of beta-END on all behaviors tested. The delta receptor antagonist ICI-154,129 (12.5 and 50 micrograms ICV) only partially reversed the sexual effects of beta-END but completely reversed the open field effects. It is concluded that the suppressive effect of beta-END on sexual behavior, while not behaviorally specific, is not secondary to opioid-induced akinesia.
将旷场行为与交配行为相结合进行观察，以辨别脑室内（ICV）注射β-内啡肽（β-END）对性行为的影响是否继发于运动不能。三组去卵巢、经雌激素-孕激素预处理的大鼠分别接受了生理盐水ICV、2微克β-END ICV或2微克β-END ICV与一种选择性阿片受体拮抗剂联合使用的平衡处理。β-END持续抑制接受行为（脊柱前凸）和求偶行为（呈现和摆耳），而对走动没有影响。直立和梳理行为总体上减少，尽管仅在一项实验中这种影响具有统计学意义。用μ-1拮抗剂纳洛唑酮（50毫克/千克静脉注射）预处理可逆转β-END对所有测试行为的影响。δ受体拮抗剂ICI-154,129（12.5和50微克ICV）仅部分逆转β-END的性效应，但完全逆转旷场效应。得出的结论是，β-END对性行为的抑制作用虽然不是行为特异性的，但并非继发于阿片类药物诱导的运动不能。
