杏仁核和催产素作为理解和治疗自闭症的关键：基于 RDoC 的方法述评。
Amygdala and oxytocin functioning as keys to understanding and treating autism: Commentary on an RDoC based approach.
机构信息
Department of Social Neuroscience, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraße 1A, 04107 Leipzig, Germany.
Department of Social Neuroscience, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraße 1A, 04107 Leipzig, Germany; Chair of Clinical Psychology and Behavioral Neuroscience, Faculty of Psychology, Technische Universität Dresden, Chemnitzer Str. 46, 01187 Dresden, Germany.
出版信息
Neurosci Biobehav Rev. 2018 Nov;94:45-48. doi: 10.1016/j.neubiorev.2018.08.012. Epub 2018 Aug 24.
The recent review by Hennessey, Andari and Rainnie (2018) utilizes the proposed Research Domain Criteria (RDoC) to classify amygdala functions and relate them to autism symptomatology. This approach has the potential to challenge the overarching autism diagnosis by furthering our knowledge of the mechanisms giving rise to autism psychopathology and generate novel treatment options. The purpose of this commentary is to provide additional information on a number of points raised in the review. Thus, (1) we discuss the issue of amygdala and brain overgrowth in children with autism and relate it to developmental oxytocin changes, (2) examine potential mechanisms that underlie amygdala overgrowth and dysfunction of the oxytocin system, (3) zoom in on the sexually dimorphic characteristics of the amygdala and potential parallels with the oxytocin system and (4) discuss how the interplay of oxytocin and vasopressin may explain the partially inconsistent findings of their effects on amygdala functioning.
最近，Hennessey、Andari 和 Rainnie（2018）的综述利用了提出的研究领域标准（RDoC）来对杏仁核功能进行分类，并将其与自闭症症状联系起来。这种方法有可能通过深入了解导致自闭症病理的机制，并提出新的治疗选择，来挑战自闭症的总体诊断。本文的目的是就综述中提出的若干观点提供更多信息。因此，（1）我们讨论了自闭症儿童的杏仁核和大脑过度生长问题，并将其与发育性催产素变化联系起来；（2）探讨了潜在的机制，这些机制是杏仁核过度生长和催产素系统功能障碍的基础；（3）详细探讨了杏仁核的性别二态性特征及其与催产素系统的潜在平行关系；（4）讨论了催产素和血管加压素的相互作用如何解释它们对杏仁核功能的影响的部分不一致发现。
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