血管紧张素II对近端肾小管重吸收的调节作用。

Modulation of proximal tubular reabsorption by angiotensin II.

作者信息

Zhuo J, Harris P J, Skinner S L

出版信息

Clin Exp Pharmacol Physiol. 1986 Apr;13(4):277-81. doi: 10.1111/j.1440-1681.1986.tb00348.x.

DOI:10.1111/j.1440-1681.1986.tb00348.x

Abstract

In shrinking-drop micropuncture studies in anaesthetized rats proximal tubular fluid reabsorption (JVa) decreased by 36% following intravenous infusion of enalapril. In a separate group of rats enalapril reduced fractional lithium clearance indicating decreased proximal fluid reabsorption. Following enalapril, GFR rose by 46% but absolute proximal reabsorption rose by 22% indicating 48% effectiveness of proximal glomerulo-tubular balance (GTB). Since renal blood flow and glomerular filtration rate (GFR) increased in parallel and arterial pressure fell, fluid uptake and proximal GTB were unlikely to have been decreased by peritubular physical forces. In anaesthetized rats proximal fluid reabsorption and proximal GTB are modulated by endogenous AII through direct stimulation of proximal tubular transport.

摘要

在对麻醉大鼠进行的缩滴微穿刺研究中，静脉输注依那普利后近端肾小管液重吸收（JVa）下降了36%。在另一组大鼠中，依那普利降低了锂清除分数，表明近端液体重吸收减少。给予依那普利后，肾小球滤过率（GFR）上升了46%，但近端绝对重吸收仅上升了22%，表明近端球管平衡（GTB）的有效性为48%。由于肾血流量和肾小球滤过率（GFR）平行增加且动脉血压下降，肾小管周围物理力不太可能导致液体摄取和近端GTB降低。在麻醉大鼠中，内源性血管紧张素II通过直接刺激近端肾小管转运来调节近端液体重吸收和近端GTB。