Stolowy N, Callet M, Beylerian M, Hoffart L, Yin G Ho Wang
Service d'ophtalmologie, université d'Aix-Marseille, hôpital de la Timone, 264, rue Saint-Pierre, 13385 Marseille cedex 05, France.
Service d'ophtalmologie, université d'Aix-Marseille, hôpital de la Timone, 264, rue Saint-Pierre, 13385 Marseille cedex 05, France.
J Fr Ophtalmol. 2018 Sep;41(7):642-649. doi: 10.1016/j.jfo.2017.11.039. Epub 2018 Aug 28.
Keratoprostheses offer a therapeutic alternative to patients with bilateral corneal blindness who cannot undergo corneal allograft. The goal of this work was to evaluate the indications and limitations of Boston keratoprosthesis.
Seven patients underwent unilateral implantation of a Boston type I keratoprosthesis between December 2012 and November 2016. The following data were collected: surgical indication, preoperative visual acuity, postoperative visual acuity at D1, D7, D30, 6 months and 12 months, complications and postoperative treatment.
The mean age of implantation was 58.7±23.4 years. The surgical indications included 1 case of congenital bilateral aniridia, 2 cases of chemical burn and 4 graft decompensations after multiple keratoplasties. Preoperative visual acuity was limited to "light perception" in 6 cases and "hand motion" in one case. A gain in visual acuity was observed in 4 patients, which corresponded to a mean gain of 1.53 logMAR at last follow-up. Postoperative visual acuity averaged 2.33 logMAR. All patients experienced an improvement in their quality of life and independence.
Patients should be selected carefully, favoring patients with a remaining functional potential and able to engage in close postoperative follow-up, in order to ensure the best possible treatment success.
Boston keratoprosthesis provides improved vision and improved quality of life for patients suffering from bilateral corneal blindness.
角膜移植假体为无法接受同种异体角膜移植的双侧角膜盲患者提供了一种治疗选择。本研究的目的是评估波士顿角膜移植假体的适应症和局限性。
2012年12月至2016年11月期间,7例患者接受了单侧波士顿I型角膜移植假体植入术。收集了以下数据:手术适应症、术前视力、术后第1天、第7天、第30天、6个月和12个月时的视力、并发症及术后治疗情况。
植入时的平均年龄为58.7±23.4岁。手术适应症包括1例先天性双侧无虹膜、2例化学伤以及4例多次角膜移植术后移植片失代偿。术前视力,6例为“光感”,1例为“手动”。4例患者视力提高,最后一次随访时平均提高1.53 logMAR。术后平均视力为2.33 logMAR。所有患者的生活质量和独立性均有所改善。
应仔细选择患者,优先选择具有剩余功能潜力且能够密切进行术后随访的患者,以确保获得最佳治疗效果。
波士顿角膜移植假体为双侧角膜盲患者改善了视力,提高了生活质量。