Tsubokawa T, Katayama Y, Yamamoto T, Hirayama T
Appl Neurophysiol. 1985;48(1-6):166-71. doi: 10.1159/000101122.
This report summarizes our clinical experience in which the effects of both thalamic sensory relay nucleus (TSRN) and periaqueductal gray (PAG) stimulation were tested in the same series of patients with various forms of pain. The clinical data indicated that neurogenic pain due to deafferentation at the level of the peripheral nerves or the spinal cord was often controlled by TSRN stimulation but not by PAG stimulation. We also review the results of our experimental investigations in cats which were undertaken in an attempt to clarify the neurophysiologic basis of such differential clinical effects of TSRN and PAG stimulation. It appeared that abnormal hyperactivity within the trigeminal medullary dorsal horn following retrogasserian rhizotomy was far more frequently inhibited by TSRN stimulation than by PAG stimulation.
本报告总结了我们的临床经验，即在同一组患有各种疼痛形式的患者中测试丘脑感觉中继核（TSRN）和导水管周围灰质（PAG）刺激的效果。临床数据表明，由外周神经或脊髓水平的传入神经阻滞引起的神经源性疼痛通常可通过TSRN刺激得到控制，但不能通过PAG刺激得到控制。我们还回顾了我们在猫身上进行的实验研究结果，这些研究旨在阐明TSRN和PAG刺激这种不同临床效果的神经生理基础。结果显示，半月节后根切断术后三叉神经延髓背角内的异常活动亢进，被TSRN刺激抑制的频率远高于被PAG刺激抑制的频率。
