肿瘤芽生在膀胱肌层浸润性尿路上皮癌中的预后意义
Prognostic significance of tumor budding in muscle invasive urothelial carcinomas of the bladder.
作者信息
Küçük Ülkü, Ekmekçi Sümeyye, Çakır Ebru, Ekin Zübeyde, Ergani Batuhan, Ekin Gökhan Rahmi
机构信息
Department of Pathology, University of Health Sciences, Tepecik Training and Research Hospital, İzmir, Turkey.
Department of Pathology, University of Katip Çelebi, Atatürk Training and Research Hospital, İzmir, Turkey.
出版信息
Turk J Urol. 2018 Aug 31;45(4):273-278. doi: 10.5152/tud.2018.58269. Print 2019 Jul.
OBJECTIVE
The aim of this study was to evaluate the prognostic significance of tumor budding in muscle invasive urothelial carcinoma of bladder (MIBC).
MATERIAL AND METHODS
A total of 60 patients who underwent radical cystectomy and cystoprostatectomy for MIBC were included in the study. The correlations between tumor budding, and tumor necrosis, lymphovascular invasion (LVI), perineural invasion (PNI) and histopathological data with distant metastasis were evaluated. The correlation between progression free (PFS) and overall survival (OS) rates and the presence, and grade of tumor budding was investigated.
RESULTS
A statistically significant correlation was not seen between tumor budding, necrosis, LVI, and PNI. There was a strong correlation between distant organ metastasis, and presence of tumor necrosis. There was no statistically significant correlation between PFS, OS and tumor budding. A statistically significant relationship was observed between OS and tumor stage, lymph node metastasis, and distant organ metastasis.
CONCLUSION
In our study, statistically significant effect of tumor budding on survival rates in MIBCs was not observed. Also, no significant correlation was observed between tumor budding and tumor necrosis, LVI, and PNI.
目的
本研究旨在评估肿瘤芽生在膀胱肌层浸润性尿路上皮癌（MIBC）中的预后意义。
材料与方法
本研究共纳入60例因MIBC接受根治性膀胱切除术和膀胱前列腺切除术的患者。评估肿瘤芽生与肿瘤坏死、淋巴管浸润（LVI）、神经周围浸润（PNI）以及组织病理学数据与远处转移之间的相关性。研究无进展生存期（PFS）和总生存期（OS）率与肿瘤芽生的存在及分级之间的相关性。
结果
肿瘤芽生、坏死、LVI和PNI之间未观察到统计学上的显著相关性。远处器官转移与肿瘤坏死的存在之间存在强相关性。PFS、OS与肿瘤芽生之间无统计学上的显著相关性。观察到OS与肿瘤分期、淋巴结转移和远处器官转移之间存在统计学上的显著关系。
结论
在我们的研究中，未观察到肿瘤芽生对MIBC生存率有统计学上的显著影响。此外，肿瘤芽生与肿瘤坏死、LVI和PNI之间未观察到显著相关性。
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