Arigami Takaaki, Uchikado Yasuto, Omoto Itaru, Sasaki Ken, Kita Yoshiaki, Owaki Tetsuhiro, Yanagita Shigehiro, Mori Shinichiro, Kurahara Hiroshi, Okumura Hiroshi, Maemura Kosei, Natsugoe Shoji
Department of Onco-biological Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Anticancer Res. 2018 Sep;38(9):5447-5452. doi: 10.21873/anticanres.12876.
To examine the depth of tumor invasion and tumor length and assess the clinical impact of the primary tumor score (PTS), based on a combination of tumor invasion and tumor length, in patients with esophageal squamous cell carcinoma (ESCC).
A total of 237 patients with ESCC were classified into three PTS groups based on cut-off values for deeper tumor invasion (pT2-T4) and greater tumor length (≥44 mm). A PTS of 2 indicated the presence of both of these abnormalities, 1 indicated one of these abnormalities, and 0 indicated neither abnormality.
PTS was significantly positively correlated with depth of tumor invasion, lymph node metastasis, lymphovascular invasion, and stage (all p<0.001). The prognosis differed significantly among the three groups based on PTS (p<0.0001). Multivariate analysis demonstrated that PTS was an independent prognostic factor (p=0.0004).
PTS has a clinical utility as a prognostic predictor in patients with ESCC.
探讨食管鳞状细胞癌（ESCC）患者肿瘤浸润深度和肿瘤长度，并评估基于肿瘤浸润和肿瘤长度的原发性肿瘤评分（PTS）的临床影响。
根据更深的肿瘤浸润（pT2 - T4）和更长的肿瘤长度（≥44 mm）的临界值，将237例ESCC患者分为三个PTS组。PTS为2表示存在这两种异常，1表示存在其中一种异常，0表示不存在任何异常。
PTS与肿瘤浸润深度、淋巴结转移、淋巴管浸润和分期均呈显著正相关（均p<0.001）。基于PTS的三组患者预后差异显著（p<0.0001）。多因素分析表明，PTS是一个独立的预后因素（p = 0.0004）。
PTS作为ESCC患者的预后预测指标具有临床应用价值。
