Kim Jong Seung, Kwon Sam Hyun, Lee So Eun, Lee Eun Jung, Lee Min Hee
Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Chonbuk National University Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju Department of Practical Music, SoHae University, Gunsan Presbyterian Medical Center, Department of Internal Medicine, Division of Allergy and Pulmonology, Jeonju, Republic of Korea.
Medicine (Baltimore). 2018 Sep;97(36):e11832. doi: 10.1097/MD.0000000000011832.
Corticosteroids are widely used to treat voice change after thyroidectomy. In this study, we evaluated the effect of a single dose of intravenous dexamethasone after thyroidectomy using a metaanalysis.
Relevant studies were identified by searching the following databases: Medline, Embase, and Cochrane through February 2017. We followed PRISMA guidelines. The following search terms were used: "thyroidectomy," "voice," "steroid." Random-effects models were used to estimate standardized mean differences (SMDs) and 95% confidence intervals.
Our search yielded one retrospective cohort study involving 122 thyroidectomy patients and 3 randomized controlled studies involving 242 thyroidectomy patients. The pooled SMD for voice quality after thyroidectomy was -0.80 (P < .05). Subgroup analysis showed significant voice quality change 1 day after administration of dexamethasone.
Single-dose intravenous dexamethasone after thyroidectomy significantly improves subjective voice quality on day 1. The effect was not different significantly after day 1.
Level 2a.
皮质类固醇被广泛用于治疗甲状腺切除术后的嗓音改变。在本研究中，我们通过荟萃分析评估了甲状腺切除术后单次静脉注射地塞米松的效果。
通过检索以下数据库来识别相关研究：截至2017年2月的Medline、Embase和Cochrane数据库。我们遵循PRISMA指南。使用了以下检索词：“甲状腺切除术”、“嗓音”、“类固醇”。采用随机效应模型来估计标准化均数差（SMD）和95%置信区间。
我们的检索得到一项涉及122例甲状腺切除患者的回顾性队列研究以及三项涉及242例甲状腺切除患者的随机对照研究。甲状腺切除术后嗓音质量的合并SMD为-0.80（P<0.05）。亚组分析显示地塞米松给药后1天嗓音质量有显著变化。
甲状腺切除术后单次静脉注射地塞米松在第1天可显著改善主观嗓音质量。第1天后效果无显著差异。
2a级。
