Kazımoğlu Hatem, Harman Rezan, Mercimek Mehmet Necmettin, Dokur Mehmet, Uysal Erdal
Department of Urology, Sanko University School of Medicine, Gaziantep, Turkey.
Department of Infectious Diseases, Sanko University School of Medicine, Gaziantep, Turkey.
Turk J Urol. 2018 Jul 27;45(1):63-69. doi: 10.5152/tud.2018.09522. Print 2019 Nov.
Infections play an important part in post-transplantation causes of morbidity and mortality. The purpose of this study is to evaluate short-, and long-term infections encountered in after renal transplantations.
Two hundred and thirteen cases that consisted of both living and cadaver donors, who suffered from late period renal insufficiency and had renal transplant between June 2011 and January 2016 at the Transplantation Center of Sanko University School of Medicine were included in the study. In this study the short-, and long-term infections seen in post renal transplantation were examined retrospectively. Infection types, frequency and periods of infection, infection agents and predisposing factors were determined as the examination parameters.
Of the 213 patients who received renal transplant, 139 were males (65.3%) and 74 were women (34.75%) and the mean age was 42±11,8 (range, 14-70) years. Twelve (5.6%) patients exited after renal transplantation. Post-transplant infections were seen in 49 patients (23.1%) within 1-6 months; in 13 patients (6.1%) within 6-12 months; and in 5 patients (2.4%) after the 12 month. The most common infections after renal transplantation were associated with urinary tract (70 patients, 34.3%). The most frequently isolated agents were E. coli (n=66; 30.9%), Kebsiella spp. (n=18; 8.4%) and Enterococci (n=18; 8.4%) respectively. The renal transplants from the cadavers were observed to contract infections 1.78 times more frequently compared to the living donors (OR=1.78, 95% CI=1.03-3.09).
The most common complication after renal transplantation are infections. The majority of the infections are seen within the first year especially between 1-6 months. Post-transplant infections are often related to urinary system. E.coli is the most frequently isolated agent and it may be responsible for urosepsis in renal transplant patients. Infection more often seen in renal transplantations from cadavers.
感染在移植后发病和死亡原因中起重要作用。本研究的目的是评估肾移植后发生的短期和长期感染情况。
本研究纳入了2011年6月至2016年1月间在三光大学医学院移植中心接受肾移植的213例患者，这些患者包括活体供体和尸体供体，均患有晚期肾功能不全。本研究对肾移植后出现的短期和长期感染进行了回顾性研究。将感染类型、感染频率和时期、感染病原体及易感因素确定为检查参数。
在接受肾移植的213例患者中，男性139例（65.3%），女性74例（34.75%），平均年龄为42±11.8岁（范围14 - 70岁）。12例（5.6%）患者肾移植后死亡。移植后1 - 6个月内，49例患者（23.1%）出现感染；6 - 12个月内，13例患者（6.1%）出现感染；12个月后，5例患者（2.4%）出现感染。肾移植后最常见的感染与泌尿系统有关（70例患者，34.3%）。最常分离出的病原体分别为大肠杆菌（n = 66；30.9%）、克雷伯菌属（n = 18；8.4%）和肠球菌（n = 18；8.4%）。观察发现，尸体供肾的感染频率是活体供肾的1.78倍（OR = 1.78，95% CI = 1.03 - 3.09）。
肾移植后最常见的并发症是感染。大多数感染发生在第一年，尤其是1 - 6个月之间。移植后感染常与泌尿系统有关。大肠杆菌是最常分离出的病原体，它可能是肾移植患者发生尿脓毒症的原因。尸体供肾的肾移植感染更为常见。
