将内源性大麻素系统理解为三叉神经对脑震荡疼痛反应的调节因子。
Understanding the endocannabinoid system as a modulator of the trigeminal pain response to concussion.
作者信息
Elliott Melanie B, Ward Sara J, Abood Mary E, Tuma Ronald F, Jallo Jack I
机构信息
Department of Neurosurgery, Vickie & Jack Farber Institute for Neuroscience Thomas Jefferson University, PA 19107, USA.
Department of Pharmacology, Lewis Katz School of Medicine, Temple University, PA 19140, USA.
出版信息
Concussion. 2017 Oct 4;2(4):CNC49. doi: 10.2217/cnc-2017-0010. eCollection 2017 Dec.
Post-traumatic headache is the most common symptom of postconcussion syndrome and becomes a chronic neurological disorder in a substantial proportion of patients. This review provides a brief overview of the epidemiology of postconcussion headache, research models used to study this disorder, as well as the proposed mechanisms. An objective of this review is to enhance the understanding of how the endogenous cannabinoid system is essential for maintaining the balance of the CNS and regulating inflammation after injury, and in turn making the endocannabinoid system a potential modulator of the trigeminal response to concussion. The review describes the role of endocannabinoid modulation of pain and the potential for use of phytocannabinoids to treat pain, migraine and concussion.
创伤后头痛是脑震荡后综合征最常见的症状，在相当一部分患者中会成为一种慢性神经疾病。本综述简要概述了脑震荡后头痛的流行病学、用于研究该疾病的研究模型以及提出的发病机制。本综述的一个目的是加深对内源性大麻素系统如何在损伤后维持中枢神经系统平衡和调节炎症至关重要的理解，进而使内源性大麻素系统成为三叉神经对脑震荡反应的潜在调节因子。该综述描述了内源性大麻素对疼痛的调节作用以及使用植物大麻素治疗疼痛、偏头痛和脑震荡的潜力。
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