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不同他汀类药物治疗动脉粥样硬化的疗效比较与分析

Comparison and analysis of the therapeutic effect of different statins in the treatment of atherosclerosis.

作者信息

Liu Meifeng, Liu Guiting, Wang Meiying

机构信息

Changyi people's Hospital, Internal Medicine-Neurology, Changyi, China.

Changyi people's Hospital, Pediatrics, Changyi, China.

出版信息

Pak J Pharm Sci. 2018 Jul;31(4(Special)):1737-1742.

Abstract

Studies have confirmed that lipid-lowering drugs can effectively control the morbidity and mortality of cardiovascular and cerebrovascular diseases and statins are the most widely used. The aim of this study is to investigate the effect and mechanism of different statins on atherosclerotic patients. The patients were randomly divided into 4 groups according to the digital method, and the patients were treated with conventional therapy, simvastatin treatment, pravastatin treatment, atorvastatin treatment. It is concluded that statins are safe, effective and reliable for the treatment of atherosclerosis, and worthy of clinical promotion. The results also showed that after 6 months of taking statins, the levels of NO and NOS increased, the thickness of carotid intima-media became thinner and the plaque score decreased. This study provides a basis for elucidating the role of statins in the body.

摘要

研究证实,降脂药物可有效控制心脑血管疾病的发病率和死亡率,他汀类药物是使用最为广泛的。本研究旨在探讨不同他汀类药物对动脉粥样硬化患者的作用及机制。患者按数字法随机分为4组,分别给予常规治疗、辛伐他汀治疗、普伐他汀治疗、阿托伐他汀治疗。结论为他汀类药物治疗动脉粥样硬化安全、有效、可靠,值得临床推广。结果还显示,服用他汀类药物6个月后,一氧化氮(NO)和一氧化氮合酶(NOS)水平升高,颈动脉内膜中层厚度变薄,斑块评分降低。本研究为阐明他汀类药物在体内的作用提供了依据。

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