Zicha J, Kunes J, Jelínek J, Leont'eva G R, Govyrin V A
Physiol Bohemoslov. 1986;35(4):308-12.
The role of sodium and its accompanying anion for the development of DOCA-salt hypertension was studied in uninephrectomized DOCA-treated weanling Wistar rats which were fed a diet containing either sodium chloride or sodium bicarbonate (170 mmol/kg). The blood pressure was increased in both groups of rats with sodium overload as compared to rats fed a low-salt diet only. A decreased cardiac output and substantially elevated systemic resistance were demonstrated in both groups of rats with high sodium intake in comparison with rats kept on a low-salt diet. However, these haemodynamic changes were more pronounced in rats with sodium chloride overload than in animals with a high sodium bicarbonate intake. On the other hand, the rigidity of major arteries which was estimated as the pulse pressure/stroke volume ratio, was increased only in rats fed a diet with sodium chloride but not in rats with sodium bicarbonate overload. Thus high sodium intake was responsible for the changes of systemic resistance in DOCA-treated animals and its action was only slightly augmented by a high chloride intake. In contrast to this, the chloride overload seemed to be essential for the induction of increased arterial rigidity.
在单侧肾切除并用去氧皮质酮（DOCA）处理的断乳Wistar大鼠中，研究了钠及其伴随阴离子在DOCA-盐性高血压发展中的作用。这些大鼠喂食含氯化钠或碳酸氢钠（170 mmol/kg）的饮食。与仅喂食低盐饮食的大鼠相比，两组钠过载的大鼠血压均升高。与维持低盐饮食的大鼠相比，两组高钠摄入的大鼠心输出量降低，全身阻力显著升高。然而，这些血流动力学变化在氯化钠过载的大鼠中比在高碳酸氢钠摄入的动物中更明显。另一方面，以脉压/每搏量比值估算的主要动脉僵硬度仅在喂食含氯化钠饮食的大鼠中增加，而在碳酸氢钠过载的大鼠中未增加。因此，高钠摄入是DOCA处理动物全身阻力变化的原因，高氯摄入仅略微增强其作用。与此相反，氯过载似乎是诱导动脉僵硬度增加所必需的。
