Li Zhiliang, Jing Ke, Li Suo, Feng Suying
Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Jiangsu, China.
Postepy Dermatol Alergol. 2018 Aug;35(4):338-343. doi: 10.5114/ada.2018.77663. Epub 2018 Aug 21.
Immunoglobulin A (IgA) is the most common subtype of antibodies in mucosal surfaces. In most of autoimmune bullous diseases, however, immunoglobulin G (IgG) is the main pathogenic antibody that plays a role through complementation. The IgA antibody for epidermal connection protein can be found in the sera of some patients with blistering skin disease. Of these patients, some have the IgA antibody in their sera, while others have IgG and IgA antibodies. IgA-related autoimmune bullous diseases are less common in clinical practice. In the past, these diseases were not fully understood and their classifications were confusing. Recently, some progress has been made in the study of these diseases.
免疫球蛋白A（IgA）是黏膜表面最常见的抗体亚型。然而，在大多数自身免疫性大疱性疾病中，免疫球蛋白G（IgG）是主要的致病抗体，通过补体发挥作用。在一些皮肤水疱病患者的血清中可发现针对表皮连接蛋白的IgA抗体。在这些患者中，有些患者血清中有IgA抗体，而有些患者则同时有IgG和IgA抗体。IgA相关的自身免疫性大疱性疾病在临床实践中较少见。过去，对这些疾病了解不足，其分类也很混乱。最近，在这些疾病的研究方面取得了一些进展。
