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A型肉毒毒素注射治疗双侧斜方肌肥大患者的疗效与安全性

Efficacy and Safety of Botulinum Toxin Type A Injection in Patients with Bilateral Trapezius Hypertrophy.

作者信息

Zhou Rong-Rong, Wu Hui-Ling, Zhang Xu-Dong, Ye Li-Li, Shao Hui-Jun, Song Xin-Hui, Song Ming-Li, Zheng Shu-Sen

机构信息

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou, 310003, China.

Department of Burn and Plastic Surgery, PLA 117 Hospital, Hangzhou, 310013, China.

出版信息

Aesthetic Plast Surg. 2018 Dec;42(6):1664-1671. doi: 10.1007/s00266-018-1201-3. Epub 2018 Sep 11.

Abstract

OBJECTIVE

To evaluate aesthetic outcomes in patients with bilateral trapezius hypertrophy treated by botulinum toxin type A (BTxA) injection for aesthetic reconstruction of the upper trapezius.

METHODS

From May 2015 to May 2016, 30 women with a short neck shape resulting from bilateral trapezius hypertrophy were treated with botulinum toxin type A (BTxA) injection at the most affected area of the upper trapezius. Pre- and postoperative values of S (irregularly shaped area of the four points A, C, D, and F) and S (irregularly shaped area of the four points A, C, D, and E), responses to patients' and doctors' Global Aesthetic Improvement Scale (GAIS) questionnaires for neck aesthetic assessment, as well as reported adverse events, were recorded and analyzed.

RESULTS

Duration of follow-up ranged from 4 to 12 months. Subjects experienced non-severe adverse events and complete recovery after a single BTxA injection. In patients' GAIS questionnaires, "very much improved" accounted for 53%, "much improved" accounted for 13%, and "improved" accounted for 27%. In doctors' GAIS questionnaires, "very much improved" accounted for 27%, "much improved" accounted for 33%, "improved" accounted for 33%, and "no change" accounted for 7%. The overall degree of improvement was high. Statistically significant differences were observed with respect to the "very much improved" response to GAIS questionnaires between patients and doctors (P = 0.035).

CONCLUSION

A single injection of BTxA for aesthetic reconstruction of the upper trapezius is safe and effective in patients with bilateral trapezius hypertrophy.

LEVEL OF EVIDENCE IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

摘要

目的

评估A型肉毒毒素(BTxA)注射用于双侧斜方肌肥大患者上斜方肌美学重建的美学效果。

方法

2015年5月至2016年5月,对30例因双侧斜方肌肥大导致颈部形态不佳的女性患者,于上斜方肌最受累区域注射A型肉毒毒素(BTxA)。记录并分析术前和术后S(A、C、D、F四点构成的不规则区域面积)和S(A、C、D、E四点构成的不规则区域面积)的值、患者和医生颈部美学评估的整体美学改善量表(GAIS)问卷回复,以及报告的不良事件。

结果

随访时间为4至12个月。受试者单次注射BTxA后经历了非严重不良事件并完全恢复。在患者的GAIS问卷中,“改善非常明显”占53%,“改善明显”占13%,“有所改善”占27%。在医生的GAIS问卷中,“改善非常明显”占27%,“改善明显”占33%,“有所改善”占33%,“无变化”占7%。整体改善程度较高。患者和医生对GAIS问卷“改善非常明显”的回复存在统计学显著差异(P = 0.035)。

结论

单次注射BTxA用于双侧斜方肌肥大患者的上斜方肌美学重建是安全有效的。

证据水平IV:本刊要求作者为每篇文章指定证据水平。有关这些循证医学评级的完整描述,请参阅目录或在线作者指南www.springer.com/00266

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