1 Department of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
3 Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
J Neurotrauma. 2019 Apr 1;36(7):1168-1174. doi: 10.1089/neu.2018.5881. Epub 2018 Oct 10.
A prospective observational study collected temperature data from 51 patients in 11 neurosurgical centers and follow-up outcome information at 6 months in 49 patients. Brain temperature (T) was measured directly by an intraventricular temperature sensor. Axillary temperature (T) and rectal temperature (T) were measured by electric thermometers. T was 0.4 to 1.5°C higher than body temperature. T correlated well with the T (coefficient: 0.7378; p < 0.05). Among all patients, Glasgow Coma Scale (GCS) scores on admission were significantly lower in the patients with post-operatively extreme peak temperature (T, < 37°C or >39°C in first 24 h) and major temperature variation (T > 1°C in first 12 h; p < 0.05, p < 0.01, respectively). Among the patients with no temperature intervention, the extreme T group showed a lower Glasgow Outcome Scale-Extended (GOS-E) score at 6 months (p < 0.05) with lower GCS scores on admission (p < 0.01), compared with the moderate T group. Remarkably, the major T group showed significantly lower GOS-E scores (p < 0.05) with the same GCS scores as the minor T group. Thus, T is the better candidate to estimate T. Spontaneously extreme T in TBI represents both more serious injury on admission and worse prognosis, and T might be used as a novel prognostic parameter in TBI. Brain temperature is therefore one of the critical indicators evaluating injury severity, prognostication, and monitoring in the management of TBI. This prospective observational study has been registered in ClinicalTrials.gov ( https://clinicaltrials.gov ), and the registration number is NCT03068143.
一项前瞻性观察研究从 11 个神经外科中心的 51 名患者中收集了体温数据，并在 49 名患者中随访了 6 个月的预后信息。脑温（T）通过脑室内置温度传感器直接测量。腋温（T）和直肠温（T）通过电子体温计测量。T 比体温高 0.4 至 1.5°C。T 与 T 相关性良好（系数：0.7378；p<0.05）。在所有患者中，术后极端峰值体温（T，<37°C 或>39°C 在前 24 小时内）和主要体温变化（T 在 12 小时内>1°C；p<0.05，p<0.01）患者的入院时格拉斯哥昏迷评分（GCS）显著较低。在未进行体温干预的患者中，极端 T 组在 6 个月时格拉斯哥结局量表扩展（GOS-E）评分较低（p<0.05），入院时 GCS 评分较低（p<0.01），与中度 T 组相比。值得注意的是，主要 T 组的 GOS-E 评分明显较低（p<0.05），而 GCS 评分与轻度 T 组相同。因此，T 是估计 T 的更好候选者。TBI 中 T 的自发性极端代表入院时更严重的损伤和更差的预后，T 可能被用作 TBI 的一种新的预后参数。脑温是评估 TBI 严重程度、预后和监测的关键指标之一。这项前瞻性观察研究已在 ClinicalTrials.gov（https://clinicaltrials.gov）注册，注册号为 NCT03068143。
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